Pre-cancerous steps in carcinogenesis. Their physiological adaptive nature.
Pre-cancerous steps in carcinogenesis. Their physiological adaptive nature.
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DOI：
10.1016/0304-419x(83)90002-1
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Emmanuel Farber
中科院分区：
文献类型：
--
作者：
Emmanuel Farber
人们普遍认为，在许多器官或组织中，在不同类型的致癌刺激（包括化学物质、辐射和至少一些病毒）下，癌症的发展涉及一个循序渐进的过程，在这个过程中，经常可以看到新的细胞群[1-4]。其中一些新细胞群的功能是作为另一个新的或改变的非癌细胞群的起源地点。随着每一步的发展，这一过程显示出最终演变成恶性肿瘤群体的可能性增加，并继续经历这一进程，直到癌细胞或其宿主死亡。
It is generally accepted that cancer development in many organs or tissues and with different types of carcinogenic stimuli, including chemicals, radiations and at least some viruses, involves a stepwise process in which new cell populations are regularly seen [1-4]. Some of these new cell populations function as the sites of origin of yet another new or altered non-cancerous cell population. With each step, the process shows an increased probability of evolving ultimately into a malignant neoplastic population that continues to undergo this progression until the death of the cancer cells or of their host.