Evolution of type C viral genes: origin of feline leukemia virus
Evolution of type C viral genes: origin of feline leukemia virus
复制标题
C型病毒基因的进化：猫白血病病毒的起源
DOI：
10.1126/science.52892
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发表时间：
1975
期刊：
影响因子：
56.9
通讯作者：
G. Todaro
中科院分区：
文献类型：
--
作者：
R. Benveniste;C. Sherr;G. Todaro
在家猫及其近亲的所有组织中检测到与猫白血病病毒（FeLV）RNA相关的重复基因序列，但在亲缘关系较远的猫种中未检测到。部分同源的病毒基因序列存在于啮齿动物，特别是大鼠的DNA中。结合FeLV和内源性啮齿类C型病毒之间观察到的免疫学关系，结果得出结论，FeLV相关基因从啮齿类动物传播到猫祖先，并在猫的生殖系中永久存在。
Reiterated gene sequences related to the RNA of feline leukemia virus (FeLV) are detected in all tissues of domestic cats and their close Felis relatives but not in more distantly related Felis species. Partially homologous viral gene sequences are found in rodent, and particularly rat, DNA. Together with the immunologic relationships observed between FeLV and endogenous rodent type C viruses, the results lead to the conclusion that FeLV-related genes were transmitted from a rodent to cat ancestor and have been perpetuated in the germ line of cats.