Clinical Trial Assessment of Infrastructure Matrix Tool to Improve the Quality of Research Conduct in the Community
Clinical Trial Assessment of Infrastructure Matrix Tool to Improve the Quality of Research Conduct in the Community
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DOI：
10.1200/jop.2015.005181
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发表时间：
2016-01-01
影响因子：
--
通讯作者：
Grubbs, Stephen S.
中科院分区：
文献类型：
--
作者：
Dimond, Eileen P.;Zon, Robin T.;Grubbs, Stephen S.
Purpose:Several publications have described minimum standards and exemplary attributes for clinical trial sites to improve research quality. The National Cancer Institute (NCI) Community Cancer Centers Program (NCCCP) developed the clinical trial Best Practice Matrix tool to facilitate research program improvements through annual self-assessments and benchmarking. The tool identified nine attributes, each with three progressive levels, to score clinical trial infrastructural elements from less to more exemplary. The NCCCP sites correlated tool use with research program improvements, and the NCI pursued a formative evaluation to refine the interpretability and measurability of the tool.Methods:From 2011 to 2013, 21 NCCCP sites self-assessed their programs with the tool annually. During 2013 to 2014, NCI collaborators conducted a five-step formative evaluation of the matrix tool.Results:Sites reported significant increases in level-three scores across the original nine attributes combined (P
