Relationships between cancer pattern, country income and geographical region in Asia.
Relationships between cancer pattern, country income and geographical region in Asia.
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DOI：
10.1186/s12885-015-1615-0
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发表时间：
2015-09-03
期刊：
影响因子：
3.8
通讯作者：
Tan HM
中科院分区：
文献类型：
--
作者：
Ng CJ;Teo CH;Abdullah N;Tan WP;Tan HM
癌症发病率和死亡率因地区、性别和国家经济状况而异。虽然大多数研究侧重于全球趋势，但本研究旨在描述和分析亚洲的癌症发病率和死亡率，重点是癌症部位、性别、区域和收入状况。从GLOBOCAN 2012数据库中提取癌症的标准化发病率和死亡率。计算癌症死亡率与发病率之比（MIRs），以代表癌症生存率。数据是根据亚洲四个区域和收入进行分析的。与西方相比，亚洲的癌症发病率较低，但对于MIR，情况正好相反。在亚洲，男性最常见的癌症是肺癌、胃癌、肝癌、结肠直肠癌和食道癌，而女性最常见的癌症是乳腺癌、肺癌、宫颈癌、结肠直肠癌和胃癌。肺癌、肝癌和胃癌的MIRs最高，结肠直肠癌、乳腺癌和前列腺癌的MIRs最低。东亚和西亚的癌症发病率高于东南亚和中南亚，但这一模式与MIR相反。癌症发病率随着国家收入的增加而增加，特别是结肠直肠癌和乳腺癌，但MIR的情况正好相反。这项研究证实，亚洲各地的癌症发病率和死亡率存在很大差异。这项研究是记录和解释亚洲与世界其他地区相比癌症模式变化的第一步。本文的在线版本（doi：10.1186/s12885-015-1615-0）包含补充材料，可供授权用户使用。
Cancer incidence and mortality varies across region, sex and country’s economic status. While most studies focused on global trends, this study aimed to describe and analyse cancer incidence and mortality in Asia, focusing on cancer site, sex, region and income status. Age-standardised incidence and mortality rates of cancer were extracted from the GLOBOCAN 2012 database. Cancer mortality to incidence ratios (MIRs) were calculated to represent cancer survival. The data were analysed based on the four regions in Asia and income. Cancer incidence rate is lower in Asia compared to the West but for MIR, it is the reverse. In Asia, the most common cancers in men are lung, stomach, liver, colorectal and oesophageal cancers while the most common cancers in women are breast, lung, cervical, colorectal and stomach cancers. The MIRs are the highest in lung, liver and stomach cancers and the lowest in colorectal, breast and prostate cancers. Eastern and Western Asia have a higher incidence of cancer compared to South-Eastern and South-Central Asia but this pattern is the reverse for MIR. Cancer incidence rate increases with country income particularly in colorectal and breast cancers but the pattern is the opposite for MIR. This study confirms that there is a wide variation in cancer incidence and mortality across Asia. This study is the first step towards documenting and explaining the changing cancer pattern in Asia in comparison to the rest of the world. The online version of this article (doi:10.1186/s12885-015-1615-0) contains supplementary material, which is available to authorized users.