Hepatoprotective effects of Arctium lappa Linne on liver injuries induced by chronic ethanol consumption and potentiated by carbon tetrachloride
Hepatoprotective effects of Arctium lappa Linne on liver injuries induced by chronic ethanol consumption and potentiated by carbon tetrachloride
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DOI：
10.1159/000064549
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发表时间：
2002-09-01
影响因子：
11
通讯作者：
Wang, LY
中科院分区：
文献类型：
--
作者：
Lin, SC;Lin, CH;Wang, LY
牛蒡（牛蒡）是一种多年生草本植物，通常作为蔬菜种植。为了评估其肝保护作用，在第21天（开始治疗前1天），一组大鼠（n = 10）连续28天饲喂液体乙醇饲粮（4 g无水乙醇/ 80 ml基础液体饲粮），另一组大鼠（n = 10）在第21天（开始治疗前1天）腹腔注射0.5 ml/kg四氯化碳（CCl4）以增强肝损伤。对照组大鼠饲喂不含无水乙醇的液体基础饲粮。在给药1 d和7 d时，每天给药300 mg/kg枸杞3次，乙醇组和乙醇加CCl4组的部分生化和组织病理学参数均发生了显著变化。枸杞子显著改善了因乙醇加ccl4引起的肝损伤而恶化的各种病理生化参数，如乙醇加ccl4引起的总细胞色素P-450含量和nadph -细胞色素c还原酶活性降低，血清甘油三酯水平和脂质过氧化（可大量产生有害的过氧化和有毒的丙二醛代谢物）水平升高，血清转氨酶水平升高。甚至可以恢复谷胱甘肽含量，影响组织病理病变。这些结果表明，CCl4增强的乙醇诱导的肝毒性可以在处理1和7 d后得到缓解。黄貂鱼的肝脏保护机制至少部分归因于其抗氧化活性，其可降低肝细胞的氧化应激，或其他未知的保护机制。版权所有(C) 2002中华民国国家科学委员会和S. Karger AG，巴塞尔。
Arctium lappa Linne (burdock) is a perennial herb which is popularly cultivated as a vegetable. In order to evaluate its hepatoprotective effects, a group of rats (n = 10) was fed a liquid ethanol diet (4 g of absolute ethanol/ 80 ml of liquid basal diet) for 28 days and another group (n = 10) received a single intraperitoneal injection of 0.5 ml/kg carbon tetrachloride (CCl4) in order to potentiate the liver damage on the 21st day (1 day before the beginning of A. lappa treatment). Control group rats were given a liquid basal diet which did not contain absolute ethanol. When 300 mg/kg A. lappa was administered orally 3 times per day in both the 1-day and 7-day treatment groups, some biochemical and histopathological parameters were significantly altered, both in the ethanol group and the groups receiving ethanol supplemented with CCl4. A. lappa significantly improved various pathological and biochemical parameters which were worsened by ethanol Plus CCl4-incluced liver damage, such as the ethanol Plus CCl4-induced decreases in total cytochrome P-450 content and NADPH-cytochrome c reductase activity, increases in serum triglyceride levels and lipid peroxidation (the deleterious peroxidative and toxic malondialdehyde metabolite may be produced in quantity) and elevation of serum transaminase levels. It could even restore the glutathione content and affect the histopathological lesions. These results tended to imply that the hepatotoxicity induced by ethanol and potentiated by CCl4 could be alleviated with 1 and 7 days of A. lappa treatment. The hepatoprotective mechanism of A. lappa could be attributed, at least in part, to its antioxidative activity, which decreases the oxidative stress of hepatocytes, or to other unknown protective mechanism(s). Copyright (C) 2002 National Science Council, ROC and S. Karger AG, Basel.