Sustained low-grade pro-inflammatory state in unmedicated, remitted women with major depressive disorder as evidenced by elevated serum levels of the acute phase proteins c-reactive protein and serum amyloid a
Sustained low-grade pro-inflammatory state in unmedicated, remitted women with major depressive disorder as evidenced by elevated serum levels of the acute phase proteins c-reactive protein and serum amyloid a
复制标题
DOI：
10.1016/j.biopsych.2006.09.033
复制
发表时间：
2007-08-15
影响因子：
10.6
通讯作者：
Neumeister, Alexander
中科院分区：
文献类型：
--
作者：
Kling, Mitchel A.;Alesci, Salvatore;Neumeister, Alexander
背景：重性抑郁障碍（MDD）显示冠心病（CAD）风险增加，但机制不明。MDD在女性中比男性更常见; CAD诊断在女性中可能很困难。炎症标志物C-反应蛋白（CRP）和血清淀粉样蛋白A（SAA）的升高可预测人群中CAD风险的增加; MDD患者中关于这些标志物的数据很少，特别是在缓解患者中。我们测定了空腹血清CRP（高敏感性，CRPhs）和SAA在18名未经药物治疗、病情缓解的MDD女性中的应用（平均年龄41 ±（SD）12，体重指数（BMI）25.2 ± 4.1 kg/m2）和18名BMI匹配的健康对照受试者（年龄36 ± 10，BMI 25.3 ± 3.8 kg/m2）。结果：重复SAA和CRPhs测量在研究日之间强烈相关（SAA：r =.83，p <.001; CRPhs：r =.94，p <.001）。两个SAA（5.30 +/-3.39 vs. 2.84 +/-1.87 mg/L，p <.005）和CRPh（3.23 +/-3.17 vs. 1.12 +/-1.45 mg/L; p <0.01）在MDD女性中显著升高。缓解的、未用药的MDD女性患者SAA和CRPh升高表明促炎状态与当前抑郁症状或药物治疗无关。这些发现表明，炎症机制可能是MDD患者CAD风险增加的部分原因。
Background: Major depressive disorder (MDD) shows increased coronary artery disease (CAD) risk of unknown mechanism(s). MDD is more common in women than men; CAD diagnosis can be difficult in women. Elevations of the inflammatory markers C-reactive protein (CRP) and serum amyloid A (SAA) predict increased CAD risk in populations; few data on these markers exist in MDD, particularly in remitted patients.Methods: We measured fasting am serum CRP (high sensitivity, CRPhs) and SAA in 18 unmedicated, remitted women with MDD (mean age 41 +/- (SD) 12, body mass index (BMI) 25.2 +/- 4.1 kg/m(2)) and 18 BMI-matched healthy control subjects (age 36 10, BMI 25.3 +/- 3.8 kg/m(2)) on 2 separate occasions, ! 6 days apart.Results: Repeat SAA and CRPhs measurements strongly correlated across study days (SAA: r = .83, p < .001; CRPhs: r = .94, p < .001). Both SAA (5.30 +/- 3.39 vs. 2.84 +/- 1.87 mg/L, p < .005) and CRPhs (3.23 +/- 3.17 vs. 1.12 +/- 1.45 mg/L; p < .01) were significantly elevated in MDD women versus controls.Conclusions: Elevated SAA and CRPhs in remitted, unmedicated women with MDD indicate a pro-inflammatory state unrelated to current depressive symptoms or pharmacotherapy. These findings suggest that inflammatory mechanisms may in part underlie findings of increased CAD risk in MDD.