Platelet factor 4 regulates osteoclastic bone resorption in vitro.
Platelet factor 4 regulates osteoclastic bone resorption in vitro.
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DOI：
10.1016/0304-4165(80)90295-0
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发表时间：
1980-07
期刊：
影响因子：
--
通讯作者：
John E. Horton;J. Harper;Elvin Harper
中科院分区：
文献类型：
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作者：
John E. Horton;J. Harper;Elvin Harper
血小板因子4，抑制胶原酶从人类皮肤和粒细胞提取物，被发现在体外可逆地阻止甲状旁腺素刺激的45 Ca从胎鼠骨的释放。抑制性能是同样有效的积极吸收骨和骨刺激开始吸收。
Platelet factor 4, which inhibits collagenases derived from both human skin and granulocytic extracts, was found to block reversibly parathyroid hormone-stimulated45Ca release from fetal rat bone in vitro. The inhibitory property was equally effective in both actively resorbing bones and in bones stimulated to initiate resorption.