REDUCED CAPILLARY DENSITY IN THE MYOCARDIUM OF UREMIC RATS - A STEREOLOGICAL STUDY
REDUCED CAPILLARY DENSITY IN THE MYOCARDIUM OF UREMIC RATS - A STEREOLOGICAL STUDY
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DOI：
10.1038/ki.1992.390
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发表时间：
1992-11-01
影响因子：
19.6
通讯作者：
MALL, G
中科院分区：
文献类型：
--
作者：
AMANN, K;WIEST, G;MALL, G
使用体视学技术毛细血管，血管和心肌纤维进行了分析，在灌注固定的心脏的次全肾切除雄性Sprague-Dawley大鼠尿毒症持续时间为14个月（或其假手术对照）。与对照组相比，尿毒症大鼠的收缩压（140 +/- 20.3 mm Hg vs. 119 +/- 6.61 mm Hg）和左心室重量/体重比（3.37 +/- 0.09 mg/kg vs. 2.01 +/- 0.12 mg/kg）更高，并有轻度贫血（Hct 35.0 +/-3.16% vs. 40.4 +/- 3.3%）。毛细血管长度密度（Lv），即每单位心肌体积的毛细血管长度，在尿毒症组（2485 +/- 264 mm/mm 3 vs. 3329 +/- 194 mm/mm 3）与对照组相比显著降低（P < 0.001）。同时，尿毒症大鼠毛细血管腔的表面密度和体积密度也降低（7.95 +/- 1.69 cm 3/cm 3 vs. 11.4 +/- 1.8 cm 3/cm 3）。我们的结论是，在实验性尿毒症，心肌肥厚并不伴随着相应的增加毛细血管。
Using stereological techniques capillaries, interstitium and myocardial fibers were analyzed in perfusion-fixed hearts of subtotally nephrectomized male Sprague-Dawley rats with uremia of 14 months duration (or their sham-operated controls). Uremic rats had higher systolic blood pressure (140 +/- 20.3 mm Hg vs. 119 +/- 6.61 mm Hg) and left ventricular weight/body weight ratio (3.37 +/- 0.09 mg/kg vs. 2.01 +/- 0.12 mg/kg) than controls, and had slight anemia (Hct 35.0 +/-3.16% vs. 40.4 +/- 3.3%). Length density (Lv) of capillaries, that is, capillary length per unit myocardial volume, was significantly (P < 0.001) decreased in uremia (2485 +/- 264 mm/mm3 vs. 3329 +/- 194 mm/mm3) versus controls. In parallel, surface density and volume density of the capillary lumina were also reduced (7.95 +/- 1.69 cm3/cm3 vs. 11.4 +/- 1.8 cm3/cm3) in the uremic rats. We conclude that in experimental uremia, cardiac hypertrophy is not accompanied by a commensurate increase in capillaries.