Quality of induced sputum using a human-powered nebuliser in a mobile human immunodeficiency virus testing service in South Africa
Quality of induced sputum using a human-powered nebuliser in a mobile human immunodeficiency virus testing service in South Africa
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DOI：
10.5588/ijtld.10.0684
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发表时间：
2011-08-01
影响因子：
4
通讯作者：
Bekker, L-G.
中科院分区：
文献类型：
--
作者：
Kranzer, K.;Olson, L.;Bekker, L-G.
目的：研究使用人力（HPN）和电动雾化器（EPN）诱导痰样本的质量。方法：对于每个参与者，使用HPN和EPN诱导两份痰样本。随机分配两个雾化器的顺序。使用精确McNemar检验比较根据不同评估标准的优质痰比例。使用Wilcoxon配对符号秩检验比较咳痰时间的差异。结果：共有123人符合研究条件。9人拒绝参加，5人无法提供痰液样本。与使用EPN获得的痰液样本相比，HPN诱导的痰液样本中质量良好的痰液比例更高。产生痰液样本的中位时间为2.2分钟HPN（IQR 1.13-4.1）和2.5 min（IQR 1.4-4.1）。结论：HPN在3分钟内诱导出质量良好的痰液。该设备无需电力即可运行，不仅适用于电力不可靠的偏远诊所，而且还用于移动的服务和基于社区的强化结核病（TB）病例发现。进一步的研究需要调查由HPN诱导的痰样本中的TB产率。
OBJECTIVES: To investigate the quality of induced sputum samples using a human-powered (HPN) and an electric-powered nebuliser (EPN).METHODS: For each participant two sputum samples were induced using the HPN and the EPN. The sequence of the two nebulisers was allocated at random. The proportion of good quality sputum according to different assessment criteria was compared using an exact McNemar test. The difference in time to expectoration was compared using the Wilcoxon matched-pairs signed-rank test.RESULTS: A total of 123 individuals were eligible for the study. Nine individuals refused to participate and five were unable to produce a sputum sample. The pro-portion of good quality sputum was higher among sputum samples induced by the HPN compared to those obtained using the EPN. The median time to produce a sputum sample was 2.2 min (IQR 1.13-4.1) for the HPN and 2.5 min (IQR 1.4-4.1) for the EPN.CONCLUSION: The HPN induced good quality sputum within 3 min. The device operates without electricity and is suitable not only for remote clinics with unreliable electricity, but also for mobile services and community-based intensified tuberculosis (TB) case finding. Further research needs to investigate the yield of TB in sputum samples induced by the HPN.