Risk factors for contact lens-induced papillary conjunctivitis associated with silicone hydrogel contact lens wear.
Risk factors for contact lens-induced papillary conjunctivitis associated with silicone hydrogel contact lens wear.
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DOI：
10.1097/icl.0000000000000019
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发表时间：
2014-05
期刊：
影响因子：
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通讯作者：
Szczotka-Flynn LB
中科院分区：
文献类型：
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作者：
Tagliaferri A;Love TE;Szczotka-Flynn LB
隐形眼镜引起的乳头状结膜炎（CLPC）仍然是隐形眼镜长期佩戴期间脱落的主要原因。这项回顾性研究探讨了硅水凝胶镜片长期佩戴期间发生 CLPC 的危险因素。在对主要队列的二次分析中，使用来自参加硅水凝胶隐形眼镜 (LASH) 纵向分析 (LASH) 研究的 205 名受试者佩戴 Lotrafilcon A 硅水凝胶镜片连续佩戴长达 30 天的数据来确定 CLPC 的危险因素。感兴趣的主要协变量包括大量与晶状体相关的细菌生物负载，以及地形确定的晶状体基弧与角膜拟合关系。其他感兴趣的协变量包括既往不良事件史、一年中的时间、种族、教育水平、性别和其他受试者人口统计数据。统计分析包括单变量逻辑回归，以评估潜在风险因素对二元 CLPC 结果的影响，以及 Cox 比例风险回归，以描述这些因素对 CLPC 诊断时间的影响。在 12 个月的随访中，52 名受试者 (25%) 经历了 CLPC。没有发现 CLPC 的发展与细菌生物负荷、晶状体与角膜贴合关系、既往不良事件史、性别或种族之间存在关联。 CLPC 的发展遵循与环境过敏原当地峰值相同的季节性趋势。镜片贴合度和生物沉积（以镜片相关细菌生物负荷的形式）与长期佩戴 Lotrafilcon A 硅水凝胶镜片期间发生 CLPC 无关。
Contact lens induced papillary conjunctivitis (CLPC) continues to be a major cause of dropout during contact lens extended wear. This retrospective study explores risk factors for the development of CLPC during silicone hydrogel lens extended wear. Data from 205 subjects enrolled in the Longitudinal Analysis of Silicone Hydrogel Contact Lens (LASH) study wearing lotrafilcon A silicone hydrogel lenses for up to 30 days of continuous wear were used to determine risk factors for CLPC in this secondary analysis of the main cohort. The main covariates of interest included substantial lens-associated bacterial bioburden, and topographically determined lens base curve-to-cornea fitting relationships. Additional covariates of interest included history of prior adverse events, time of year, race, education level, gender and other subject demographics. Statistical analyses included univariate logistic regression to assess the impact of potential risk factors on the binary CLPC outcome, and Cox proportional hazards regression to describe the impact of those factors on time-to-CLPC diagnosis. Across 12 months of follow-up, 52 subjects (25%) experienced CLPC. No associations were found between CLPC development and the presence of bacterial bioburden, lens-to-cornea fitting relationships, history of prior adverse events, gender or race. CLPC development followed the same seasonal trends as the local peaks in environmental allergans. Lens fit and biodeposits, in the form of lens associated bacterial bioburden, were not associated with the development of CLPC during extended wear with lotrafilcon A silicone hydrogel lenses.