Biology and Clinical Application of Neural Stem Cells
Biology and Clinical Application of Neural Stem Cells
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DOI：
10.1159/000074492
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发表时间：
2003-12
影响因子：
3.2
通讯作者：
T. Shimazaki
中科院分区：
文献类型：
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作者：
T. Shimazaki
神经干细胞存在于哺乳动物一生中CNS的各个区域，可以在体外和体内扩增并诱导分化为神经元和神经胶质。由于这些特性，人们对神经干细胞和神经祖细胞的鉴定和表征越来越感兴趣，这些细胞既用于基础发育生物学研究，也用于损伤脑的治疗应用。将神经干细胞或其衍生物移植到宿主脑中以及通过药理学操作使内源性干细胞增殖和分化是许多神经退行性疾病和脑损伤（例如帕金森病、脑缺血和脊髓损伤）的潜在治疗方法。神经干细胞研究的持续进展为大脑修复提供了新的未来。
Neural stem cells, which exist in various regions of the CNS throughout the mammalian lifespan, can be expanded and induced to differentiate into neurons and glia in vitro and in vivo. Because of these characteristics, there has been increasing interest in the identification and characterization of neural stem cells and neural progenitor cells both for basic developmental biology studies and for therapeutic applications to the damaged brain. Transplantation of neural stem cells or their derivatives into a host brain and the proliferation and differentiation of endogenous stem cells by pharmacological manipulations are potential treatments for many neurodegenerative diseases and brain injuries, such as Parkinson’s disease, brain ischemia and spinal cord injury. Continued progress in neural stem cell research is providing a new future for brain repair.