Effect of alprazolam on ischemia and reperfusion-induced ventricular arrhythmias in the isolated perfused rat heart.
Effect of alprazolam on ischemia and reperfusion-induced ventricular arrhythmias in the isolated perfused rat heart.
复制标题
阿普唑仑对离体灌注大鼠心脏缺血和再灌注引起的室性心律失常的影响。
作者：
M. L. Kingma;J. Kingma
研究了三唑苯二氮卓类抗焦虑药阿普唑仑对离体缓冲灌注大鼠心脏缺血和再灌注性室性心律失常的影响。在心肌缺血前后给予阿普唑仑，可导致再灌注性心室颤动的发生率和持续时间呈剂量依赖性减少，且在阿普唑仑浓度为1 × 10(-3) mol/l时具有显著性。这种心脏保护作用并不适用于缺血引起的室性心律失常。总之，我们的研究结果提供了证据，证明苯二氮卓类药物能够在心肌缺血后冠状动脉再灌注的实验环境中提供心脏保护作用。
The effects of the triazolobenzodiazepine anxiolytic, alprazolam, on the incidence of ischemia- and reperfusion-induced ventricular arrhythmias was studied in the isolated buffer-perfused rat heart. Administration of alprazolam before and after myocardial ischemia resulted in a dosage-dependent reduction in the incidence and duration of reperfusion-induced ventricular fibrillation and was significant at a concentration of 1 X 10(-3) mol/l alprazolam. This cardioprotective effect was not extended to ischemia-induced ventricular dysrhythmias. In conclusion, our findings provide evidence that benzodiazepine drugs are able to provide a cardioprotective effect in the experimental setting of myocardial ischemia followed by coronary reperfusion.