The Variant rs145204276 of GAS5 is Associated with the Development and Prognosis of Gastric Cancer
The Variant rs145204276 of GAS5 is Associated with the Development and Prognosis of Gastric Cancer
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DOI：
10.15403/jgld.2014.1121.271.qjl
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发表时间：
2018-03-01
影响因子：
2.1
通讯作者：
Wang, Bingjian
中科院分区：
文献类型：
--
作者：
Li, Qianjun;Ma, Gang;Wang, Bingjian
背景和目标：生长停滞特异性转录本5（GAS 5）（长链非编码RNA）的下调与胃癌（GC）细胞增殖和不良预后相关。本研究旨在探讨GAS 5基因rs 145204276变异与中国人群胃癌预后的关系，并探讨GAS 5基因在胃癌组织中表达的调控机制。比较患者和对照组之间以及按临床病理变量分类的不同亚组患者之间rs 145204276基因型del/del和等位基因del的频率。总生存率根据Kaplan-Meier方法使用log-rank test.Results：基因型del/del的频率在患者中显著低于对照组（7.0%vs.9.1%，p = 0.001）。Kaplan-Meier分析显示del/del基因型与较高的生存率显著相关（p = 0.01）。发现晚期肿瘤患者的基因型del/del比率显著低于早期肿瘤患者（4.9% vs. 8.8%，p = 0.01）。结论：GAS 5基因rs 145204276变异与胃癌的发生、发展及预后有关。rs 145204276的等位基因del与癌症进展和转移的显著较低发生率相关。
Background & Aims: Down-regulation of the growth arrest specific transcript 5 (GAS5) (long non-coding RNA) is associated with cell proliferation of gastric cancer (GC) and a poor prognosis. We aimed to investigate whether the variant rs145204276 of GAS5 is associated with the prognosis of GC in the Chinese population, and to unveil the regulatory mechanism underlying the GAS5 expression in GC tissues.Method: 1,253 GC patients and 1,354 healthy controls were included. The frequency of the genotype del/del and the allele del of rs145204276 were compared between the patients and the controls and between different subgroups of patients classified by clinicopathological variables. The overall survival rate was analyzed according to the Kaplan-Meier method using the log-rank test.Results: The frequency of genotype del/del was significantly lower in patients than in the controls (7.0% vs. 9.1%, p = 0.001). Kaplan-Meier analysis showed that genotype del/del was significantly associated with a higher survival rate (p = 0.01). Patients with late tumor stage were found to have a significantly lower rate of genotype del/del than those with an early tumor stage (4.9% vs. 8.8%, p = 0.01). Patients with UICC III and IV were found to have a significantly lower rate of genotype del/del than those with UICC I and II (5.3% vs. 8.1%, p = 0.02).Conclusion: The variant rs145204276 of GAS5 is associated with the development and prognosis of GC. The allele del of rs145204276 is associated with a remarkably lower incidence of cancer progression and metastasis.