Generation of an integration-free induced pluripotent stem cell (iPSC) line (ZZUNEUi003-A) from a Wilson's disease patient harboring a homozygous R778L mutation in ATP7B gene.
Generation of an integration-free induced pluripotent stem cell (iPSC) line (ZZUNEUi003-A) from a Wilson's disease patient harboring a homozygous R778L mutation in ATP7B gene.
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从 ATP7B 基因中携带纯合 R778L 突变的威尔逊病患者中生成无整合诱导多能干细胞 (iPSC) 系 (ZZUNEUi003-A)。
DOI：
10.1016/j.scr.2019.101664
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发表时间：
2019
影响因子：
1.2
通讯作者：
Xunhua Li
中科院分区：
文献类型：
--
作者：
Jiwei Zhang;Liting Wei;Ding;Li Feng;Chao Wu;Rui Wang;Xunhua Li
人IPSC系ZZUNEUi 003-A使用非整合重编程方法从患有威尔逊病的32岁男性患者产生，该患者在ATP 7 B基因中携带纯合R778 L突变。该细胞系在体外和体内均显示出多能性，并且具有正常的核型。
Human IPSC Line, ZZUNEUi003-A, was generated from a 32-year-old male patient with Wilson's Disease carrying a homozygous R778L mutation in ATP7B gene, using non-integrative reprogramming method. This cell line shows pluripotency both in vitro and vivo, and has a normal karyotype.