Activation peptide of the coagulation factor XIII (AP-F13A1) as a new biomarker for the screening of colorectal cancer.
Activation peptide of the coagulation factor XIII (AP-F13A1) as a new biomarker for the screening of colorectal cancer.
复制标题
凝血因子 XIII 激活肽（AP - F13A1）作为一种用于结直肠癌筛查的新型生物标志物。
DOI：
10.1186/s12014-018-9191-3
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发表时间：
2018
影响因子：
3.8
通讯作者：
Camoin L
中科院分区：
文献类型：
--
作者：
Peltier J;Roperch JP;Audebert S;Borg JP;Camoin L
Colorectal cancer (CRC) remains a major cause of cancer fatalities in developed countries. The risk of death is correlated to the stage of CRC during the primary diagnosis. Early diagnosis is closely associated with enhanced survival rate. We therefore investigated the AP-F13A1 as a potential protein marker of CRC. The protein expression of FXIII in 40 serum samples was evaluated by enzyme-linked immunosorbent assays. Additionally, targeted proteomic assays (LC-PRM) were used to evaluate the expression of the activation peptide of F13A1 (AP-F13A1) in a further 113 serum samples. Results were analyzed by the Wilcoxon test and receiver operating characteristic curves generated to assess statistical differences and diagnostic factors between CRC patients and controls. AP-F13A1 was quantified in human serum samples using calibration curves with excellent linearity. AP-F13A1 was reduced in CRC patients using PRM assays from two distinct biobanks. The AUC for AP-F13A1 were 0.95 and 0.93. Sensitivity/specificity values for the two sets of patients were 75%/95% and 71%/95% respectively. We have presented the proof of principle that in vivo release of AP-F13A1 can be measured by PRM-based strategies in CRC serum samples. AP-F13A1 may be an effective serological biomarker as part of a screening program of CRC detection. The online version of this article (10.1186/s12014-018-9191-3) contains supplementary material, which is available to authorized users.
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影响因子：
7.5
作者：
Ramacciotti, E;Wolosker, N;Franco, RF
通讯作者：
Franco, RF
影响因子：
168.9
作者：
Cunningham, David;Atkin, Wendy;Starling, Naureen
通讯作者：
Starling, Naureen
影响因子：
6.4
作者：
Stegeman, Inge;de Wijkerslooth, Thomas R.;Bossuyt, Patrick M.
通讯作者：
Bossuyt, Patrick M.
影响因子：
3.4
作者：
Fu, Q;Garnham, CP;Van Eyk, JE
通讯作者：
Van Eyk, JE
DOI：
10.1161/01.atv.0000081636.25235.c6
发表时间：
2003-08-01
影响因子：
8.7
作者：
Dardik, R;Solomon, A;Inbal, A
通讯作者：
Inbal, A