Can quinolones cause hemorrhagic colitis of late onset?
Can quinolones cause hemorrhagic colitis of late onset?
复制标题
喹诺酮类药物会引起迟发性出血性结肠炎吗？
DOI：
10.1007/bf02235056
复制
发表时间：
1999
影响因子：
3.9
通讯作者：
M. Fujishima
中科院分区：
文献类型：
--
作者：
H. Koga;K. Aoyagi;Ryuji Yoshimura;Yutaka Kimura;M. Iida;M. Fujishima
PURPOSE:This study was undertaken to demonstrate that quinolones may cause acute colitis resembling penicillin-induced hemorrhagic colitis.METHODS:We reviewed the medical records of patients with acute colitis in our institutes. Twenty-eight patients with acute hemorrhagic colitis in which no pathogenic microorganisms were identified were the subjects of this study. Pseudomembranous colitis caused by Clostridium difficile was excluded. Ulcerative colitis, Crohn's disease, and radiation proctocolitis were also excluded.RESULTS:Among these patients, 25 had a history of recent administration of penicillin derivatives. The remaining three patients had never been given any penicillin derivatives, but had ingested quinolones approximately four weeks before the developing colitis had been identified. Klebsiella oxytoca was also isolated in these three patients.CONCLUSIONS:Quinolones may cause acute hemorrhagic colitis. The time interval from antibiotic ingestion to onset of the condition may be much longer in quinolones than in penicillin derivatives.
