Dose-dependent genotype effects of BDNF Val66Met polymorphism on default mode network in early stage Alzheimer's disease.
Dose-dependent genotype effects of BDNF Val66Met polymorphism on default mode network in early stage Alzheimer's disease.
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DOI：
10.18632/oncotarget.11027
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发表时间：
2016-08-23
期刊：
影响因子：
--
通讯作者：
Chang CC
中科院分区：
文献类型：
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作者：
Lin PH;Tsai SJ;Huang CW;Mu-En L;Hsu SW;Lee CC;Chen NC;Chang YT;Lan MY;Chang CC
In humans, brain-derived neurotrophic factor (BDNF) has been shown to play a pivotal role in neurocognition, and its gene contains a functional polymorphism (Val66Met) that may explain individual differences in brain volume and memory-related activity. In this study, we enrolled 186 Alzheimer's disease (AD) patients who underwent 3D T1 magnetic resonance imaging, and explored the gray matter (GM) structural covariance networks (SCN). The patients were divided into three groups according to their genotype: Met/Met (n = 45), Val/Met (n = 86) and Val/Val (n = 55). Seed-based analysis was performed focusing on four SCN networks. Neurobehavioral scores served as the major outcome factor. Only peak cluster volumes of default mode medial temporal lobe network showed significant genotype interactions, of which the interconnected peak clusters showed dose-dependent genotype effects. There were also significant correlations between the cognitive test scores and interconnected-cluster volumes, especially in the orbitofrontal cortex. These findings support the hypothesis that BDNF rs6265 polymorphisms modulate entorhinal cortex-interconnected clusters and the valine allele was associated with stronger structural covariance patterns that determined the cognitive outcomes.
DOI：
10.1177/1533317514552667
发表时间：
2015-06
期刊：
American journal of Alzheimer's disease and other dementias
影响因子：
--
作者：
Tsai RM;Leong JK;Dutt S;Chang CC;Lee AK;Chao SZ;Yokoyama JS;Tse M;Kramer JH;Miller BL;Rosen HJ
通讯作者：
Rosen HJ