Ethanol-induced disturbances of gliogenesis and neuronogenesis in the developing murine brain: an in vitro and in vivo immunohistochemical and ultrastructural study.
Ethanol-induced disturbances of gliogenesis and neuronogenesis in the developing murine brain: an in vitro and in vivo immunohistochemical and ultrastructural study.
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乙醇诱导的小鼠大脑发育中的胶质细胞生成和神经原发生的紊乱：一项体外和体内免疫组织化学和超微结构研究。
作者：
P. Gressens;M. Lammens;J. Picard;P. Evrard
在全胚胎培养模型和活体模型上研究了乙醇对小鼠脑发育的影响。乙醇局部增加原始神经上皮细胞的死亡。在神经元迁移过程中，乙醇会导致放射状胶质引导提前转化为星形胶质细胞。乙醇也会抑制晚期胶质细胞的形成。由此产生的迁移后新皮质显示了一种异常的神经元模式，几乎完全没有垂直柱状化。这些神经胶质-神经元的紊乱可以解释胎儿酒精综合征的神经病理和临床特征。我们的研究也为研究神经发生早期正常和异常情况下的细胞死亡提供了实验工具。
The effects of ethanol on murine brain development were studied in a model of whole embryo culture and in vivo. Ethanol locally enhances cell death in the primitive neuroepithelium. During neuronal migration, ethanol induces a premature transformation of the radial glial guides into astrocytes. Ethanol also inhibits the late gliogenesis. The resulting postmigratory neocortex displays an abnormal neuronal pattern almost completely deprived of vertical columnization. These glial-neuronal disturbances can explain neuropathological and clinical features of the fetal alcohol syndrome. Our study provides also an experimental tool for the study of cell death in normal and abnormal conditions at early stages of neurogenesis.