Renal dysfunction in acute stroke: an independent predictor of long-term all combined vascular events and overall mortality
Renal dysfunction in acute stroke: an independent predictor of long-term all combined vascular events and overall mortality
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DOI：
10.1093/ndt/gfn471
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发表时间：
2009-01-01
影响因子：
6.1
通讯作者：
Vemmos, Konstantinos N.
中科院分区：
文献类型：
--
作者：
Tsagalis, George;Akrivos, Theodore;Vemmos, Konstantinos N.
背景急性中风是西方社会中仅次于缺血性心脏病和癌症的第三大死亡原因。虽然它是一种急诊疾病，与缺血性心脏病有相同的动脉粥样硬化危险因素，但对肾功能与卒中的关系研究甚少。本研究旨在评估急性脑卒中患者的肾功能状态，并探讨其预后意义。这是一项对住院10年以上的首次卒中患者进行的前瞻性研究。研究人群包括1350例卒中发作后24小时内入院的患者，随访1至120个月或直至死亡。根据估算的肾小球滤过率（eGFR）将患者分为3组，eGFR是根据肾脏疾病改良饮食的简化公式计算的，单位为ml/min/1.73m2体表面积：A组包括eGFR > 60的患者，B组包括eGFR> 30的患者。
Background. Acute stroke is the third leading cause of death in western societies after ischemic heart disease and cancer. Although it is an emergency disease sharing the same atherosclerotic risk factors with ischemic heart disease, the association of renal function and stroke is poorly investigated. The present study aims at assessing renal function status in patients with acute stroke and investigate any prognostic significance on the outcome.Methods. This is a prospective study of hospitalized first-ever stroke patients over 10 years. The study population comprised 1350 patients admitted within 24 h from stroke onset and followed up for 1 to 120 months or until death. Patients were divided in 3 groups on the basis of the estimated Glomerular Filtration Rate (eGFR) that was calculated from the abbreviated equation of the Modification Diet for Renal Disease in ml/min/1.73m(2) of body surface area: Group-A comprised patients who had eGFR > 60, group-B those with 30