Real-Time Value Integration during Economic Choice Is Regulated by Orbitofrontal Cortex
Real-Time Value Integration during Economic Choice Is Regulated by Orbitofrontal Cortex
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DOI：
10.1016/j.cub.2019.10.058
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发表时间：
2019-12-16
期刊：
影响因子：
9.2
通讯作者：
Schoenbaum, Geoffrey
中科院分区：
文献类型：
--
作者：
Gardner, Matthew P. H.;Conroy, Jessica C.;Schoenbaum, Geoffrey
神经关联涉及眼眶额叶皮质(OFC)在基于价值或经济决策中的作用[1-3]。然而，在执行啮齿动物版本的标准经济选择任务的大鼠中，OFC的失活没有效果[4，5]，这一发现更符合这样的观点，即当必须考虑新信息时，OFC对于行为是主要必要的[10-16]。OFC中的神经活动会自发更新以反映新的信息，特别是关于结果的信息[10-16]，只有在这些条件下，OFC才是调整学习行为所必需的[4，16-26]。在这里，我们通过在经济选择期间停用横向OFC来合并这两个独立的研究线路，该经济选择需要将有关预测结果的价值的新信息纳入到已经建立的选择中。在测试之前，通过预先喂食两种食物中的一种来改变结果值。在对照组大鼠中，这种预喂食导致选择行为的不同变化，这取决于大鼠对预喂食食物的先前偏好。OFC的光基因失活破坏了这种预摄食的双向效应，而不影响描述潜在选择行为的其他指标。这一发现将OFC在经济选择中的角色与其在许多其他行为中的角色统一起来，因果关系地表明，OFC本身并不是经济选择所必需的--除非这种选择包含了关于结果的新信息。
Neural correlates implicate the orbitofrontal cortex (OFC) in value-based or economic decision making [1-3]. Yet inactivation of OFC in rats performing a rodent version of the standard economic choice task is without effect [4, 5], a finding more in accord with ideas that the OFC is primarily necessary for behavior when new information must be taken into account [10-16]. Neural activity in the OFC spontaneously up- dates to reflect new information, particularly about outcomes [10-16], and the OFC is necessary for adjustments to learned behavior only under these conditions [4,16-26]. Here, we merge these two in- dependent lines of research by inactivating lateral OFC during an economic choice that requires new information about the value of the predicted outcomes to be incorporated into an already established choice. Outcome value was changed by pre-feeding the rats one of two food options before testing. In control rats, this pre-feeding resulted in divergent changes in choice behavior that depended on the rats' prior preference for the pre-fed food. Optogenetic inactivation of the OFC disrupted this bi-directional effect of pre-feeding without affecting other measures that describe the underlying choice behavior. This finding unifies the role of the OFC in economic choice with its role in a host of other behaviors, causally demonstrating that the OFC is not necessary for economic choice per se-unless that choice incorporates new information about the outcomes.