Reducing risk exposures to zero and not having multiple partners: findings that inform evidence-based practices designed to prevent STD acquisition
Reducing risk exposures to zero and not having multiple partners: findings that inform evidence-based practices designed to prevent STD acquisition
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DOI：
10.1258/095646205774988037
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发表时间：
2005-12-01
影响因子：
1.4
通讯作者：
Broadwell, SD
中科院分区：
文献类型：
--
作者：
DiClemente, RJ;Crosby, RA;Broadwell, SD
我们的目的是前瞻性地评估减少阴茎阴道风险暴露为零，并限制性伴侣的数量为一个，在获得生物学证实的性传播疾病（STD）之间的非洲裔美国女性adolescents.Data从一个前瞻性队列的522名非洲裔美国女性青少年参加了艾滋病毒预防试验的相对贡献。基线STD检测和单剂量直接观察治疗提供了一个无感染的队列，每隔6个月对这些队列进行随访和评估。在基线、6个月、12个月和18个月对自我给药的阴道拭子标本进行沙眼衣原体、淋病奈瑟菌和阴道毛滴虫检测。在每六个月的评估间隔内，测量有多个性伴侣和无保护阴道性行为的频率。报告有多个性伴侣的青少年，相对于只有一个性伴侣，更有可能检测出STD阳性（调整后的比值比（AOR）= 2.9; P = 0.0001）。报告无保护阴道性行为的青少年相对于那些报告有保护阴道性行为的青少年也有更大的机会测试阳性的性病（AOR = 1.5; P = 0.0001）。前瞻性研究结果表明，有多个性伴侣和从事无保护阴道性行为都仍然是重要的危险因素，性病收购非洲裔美国青少年妇女。性传播疾病预防方案需要针对这两个风险因素，以实现最佳的降低风险效果。
Our objective was to assess prospectively the relative contribution of reducing penile-vaginal risk exposure to zero and limiting the number of sex partners to one, on the acquisition of biologically confirmed sexually transmitted disease (STD) among African American women adolescents.Data from a prospective cohort of 522 African American women adolescents enrolled in an HIV prevention trial were used. Baseline STD testing and single-dose directly observable treatment provided an infection-free cohort, who were followed and assessed at six-month intervals.Self-administered vaginal swab specimens were tested for Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis at baseline, six, 12, and 18 months. Frequency of having multiple sex partners and unprotected vaginal sex over each six-month assessment interval was measured.Adolescents who reported multiple sex partners, relative to only one partner, were more likely to test positive for an STD (adjusted odds ratio (AOR) = 2.9; P = 0.0001). Adolescents who reported unprotected vaginal sex relative to those reporting protected vaginal sex also had greater odds of testing positive for an STD (AOR = 1.5; P = 0.0001).Prospective findings suggest that having multiple sex partners and engaging in unprotected vaginal sex both remain significant risk factors for STD acquisition among African American adolescent women. STD prevention programmes need to target both risk factors to achieve optimal risk-reduction effectiveness.