Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene
Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene
复制标题
DOI：
10.1152/ajpgi.00285.2004
复制
发表时间：
2005-02-01
影响因子：
4.5
通讯作者：
Tso, P
中科院分区：
文献类型：
--
作者：
Jandacek, RJ;Anderson, N;Tso, P
氯化烃是亲脂的，有毒的，并且在环境和动物组织中持久存在。它们通过食物进入人体并储存在脂肪组织中。通过限制热量来减少体内脂肪，可以调动储存的亲脂性异种素，并将其分配到其他组织。我们在老鼠身上研究了这个过程的可逆性，这些老鼠遵循体重循环的养生法。体重增加之后是体重减少，第二次增加，第二次减少（“溜溜球饮食法”）。我们测量了口服灌胃[C-14]六氯苯的分布，它是少量代谢的。我们发现体重循环对不同的器官有不同的影响。持续的体重减轻导致大脑中碳-14的数量和浓度增加了三倍。体重恢复后，大脑中的碳-14减少，但在第二次减肥后又增加。体重减轻导致脂肪组织中C-14的浓度增加，但不改变组织中的总量。体重减轻和恢复导致肝脏中C-14的增加，这反映了肝脏中脂肪的增加。在用[C-14]六氯苯灌胃的小鼠中重复增重和减重的方案，其中一组在饮食中接受不可吸收的脂肪酯。与随意饮食或单独减少热量饮食相比，将饮食中的油脂和热量限制相结合可使碳-14的排泄率增加30倍。限制饮食导致的C-14在大脑中的分布通过食用橄榄油减少了50%。
Chlorinated hydrocarbons are lipophilic, toxic, and persistent in the environment and animal tissues. They enter the body in food and are stored in adipose tissue. Loss of body fat through caloric restriction mobilizes stored lipophilic xenobiotics and results in distribution to other tissues. We have studied the reversibility of this process in mice that followed a regimen of body weight cycling. Weight gain was followed by weight loss, a second gain, and a second loss ("yo-yo diet regimen"). We measured the distribution of orally gavaged [C-14]hexachlorobenzene, which is sparingly metabolized. We found that weight cycling has different effects in different organs. Continued weight loss resulted in a threefold increase of C-14 amount and concentration in the brain. After weight regain, C-14 in the brain decreased but then increased again after a second weight loss. Weight loss resulted in an increase in the concentration of C-14 in adipose tissue without changing the total amount in that tissue. Weight loss and regain resulted in an increase of C-14 in the liver, which reflected an increase of fat in the liver. The regimen of weight gain and loss was repeated in mice gavaged with [C-14] hexachlorobenzene, with one group receiving the nonabsorbable fat olestra in the diet. Combined dietary olestra and caloric restriction caused a 30-fold increase in the rate of excretion of C-14 relative to an ad libitum diet or a reduced caloric diet alone. Distribution of C-14 into the brain resulting from the restricted diet was reduced by 50% by dietary olestra.