Phase I study of stereotactic radiosurgery in patients with locally advanced pancreatic cancer
Phase I study of stereotactic radiosurgery in patients with locally advanced pancreatic cancer
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DOI：
10.1016/j.ijrobp.2003.11.004
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发表时间：
2004-03-15
影响因子：
7
通讯作者：
Bastidas, JA
中科院分区：
文献类型：
--
作者：
Koong, AC;Le, QT;Bastidas, JA
目的：探讨对局部晚期胰腺癌患者实施立体定向放射外科治疗的可行性和毒性。方法和材料：纳入本研究的I期剂量递增研究，包括东部合作肿瘤组评分小于或等于2的局部晚期胰腺癌患者。患者接受了原发肿瘤的单次放射外科治疗，包括15Gy20Gy25Gy.急性胃肠道毒性按放射治疗肿瘤学组标准进行评分。结果：15例患者接受了3种剂量水平的治疗(3例接受15Gy3例接受20Gy5例接受25Gy7例)。在这些剂量下，没有观察到3级或更高的急性胃肠道毒性。这项试验在达到任何剂量限制毒性之前就停止了，因为在25GY治疗的6名可评估患者都达到了局部控制的临床目标。结论：对局部晚期胰腺癌患者进行立体定向放射外科治疗是可行的。在没有明显急性胃肠道毒性的情况下实现局部控制的推荐剂量为25Gy.(C)2004年爱思唯尔公司。
Purpose: To determine the feasibility and toxicity of delivering stereotactic radiosurgery to patients with locally advanced pancreatic cancer.Methods and Materials: Patients with Eastern Cooperative Oncology Group performance status less than or equal to2 and locally advanced pancreatic cancer were enrolled on this Phase I dose escalation study. Patients received a single fraction of radiosurgery consisting of either 15 Gy, 20 Gy, or 25 Gy to the primary tumor. Acute gastrointestinal toxicity was scored according to the Radiation Therapy Oncology Group criteria. Response to treatment was determined by serial high-resolution computed tomography scanning.Results: Fifteen patients were treated at 3 dose levels (3 patients received 15 Gy, 5 patients received 20 Gy, and 7 patients received 25 Gy). At these doses, no Grade 3 or higher acute gastrointestinal toxicity was observed. This trial was stopped before any dose-limiting toxicity was reached, because the clinical objective of local control was achieved in all 6 evaluable patients treated at 25 Gy.Conclusions: It is feasible to deliver stereotactic radiosurgery to patients with locally advanced pancreatic cancer. The recommended dose to achieve local control without significant acute gastrointestinal toxicity is 25 Gy. (C) 2004 Elsevier Inc.