A nitroolefin functionalized BODIPY chemodosimeter for biothiols driven by an unexpected conjugated addition mechanism.
A nitroolefin functionalized BODIPY chemodosimeter for biothiols driven by an unexpected conjugated addition mechanism.
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DOI：
10.1039/c2cc33749e
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发表时间：
2012-08
影响因子：
4.9
通讯作者：
M. Zhang;Yangchun Wu;Shengzhou Zhang;Hongnian Zhu;Qiong Wu;Lijuan Jiao;Erhong Hao
中科院分区：
文献类型：
--
作者：
M. Zhang;Yangchun Wu;Shengzhou Zhang;Hongnian Zhu;Qiong Wu;Lijuan Jiao;Erhong Hao
制备弱荧光硝基烯烃官能化的BODIPY 1，并通过对BODIPY的氮杂富烯环的意外共辄加成与硫醇快速反应，以产生高荧光BODIPY 4和5。该反应适用于高选择性和灵敏度的检测在活细胞中的半胱氨酸。
A weakly fluorescent nitroolefin functionalized BODIPY 1 was prepared and rapidly reacted with thiols through an unexpected conjugated addition to the azafulvene ring of BODIPY to generate highly fluorescent BODIPYs 4 and 5. This reaction was applied for the highly selective and sensitive detection of Cys in living cells.