Age and androgen-deprivation therapy on exercise outcomes in men with prostate cancer
Age and androgen-deprivation therapy on exercise outcomes in men with prostate cancer
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DOI：
10.1007/s00520-011-1169-x
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发表时间：
2012-05-01
影响因子：
3.1
通讯作者：
Kenny, Glen P.
中科院分区：
文献类型：
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作者：
Alberga, Angela S.;Segal, Roanne J.;Kenny, Glen P.
目的本研究的目的是检验年龄的影响（65岁）和雄激素剥夺疗法（ADT，存在或不存在）作为可能预测前列腺癌患者24周运动计划后身体成分和健身变化的因素。（1）有氧运动（AE），（2）抗阻运动（RE），或（3）日常护理（UC）。DXA评估身体成分。通过最大跑步机测试评估有氧健身能力。肌肉力量评估腿伸展和卧推使用八个重复的最大测试。结果年龄和ADT对身体成分或健康的影响似乎没有相互作用，65岁的参与者身体成分也没有任何显着变化，AE（p=0.013）和UC（p=0.006）的瘦体重下降，但在RE中保留。在接受ADT治疗的受试者中，AE（p=0.003）和UC（p=0.003）的瘦体重降低，
Purpose The purpose of this study is to examine the effects of age (65 years) and androgen-deprivation therapy (ADT, presence or absence) as factors that may predict changes in body composition and fitness following a 24-week exercise program in prostate cancer patients.Methods One hundred twenty-one men were randomly allocated to either: (1) aerobic exercise (AE), (2) resistance exercise (RE), or (3) usual care (UC). Body composition was assessed by DXA. Aerobic fitness was assessed through a maximal treadmill test. Muscular strength was assessed by leg extension and bench press using the eight-repetition maximum test. Responses were compared between younger (65 years) patients with or without ADT.Results There did not appear to be an interaction between age and ADT on body composition or fitness, nor were there any significant changes in body composition for participants 65 years, lean mass decreased in AE (p=0.013) and UC (p=0.006), but was preserved in RE. In participants receiving ADT, there was a decrease in lean mass in AE (p=0.003) and UC (p