IL-33-Dependent Group 2 Innate Lymphoid Cells Promote Cutaneous Wound Healing.
IL-33-Dependent Group 2 Innate Lymphoid Cells Promote Cutaneous Wound Healing.
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DOI：
10.1038/jid.2015.406
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发表时间：
2016-02
期刊：
影响因子：
--
通讯作者：
Volk SW
中科院分区：
文献类型：
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作者：
Rak GD;Osborne LC;Siracusa MC;Kim BS;Wang K;Bayat A;Artis D;Volk SW
皮肤屏障的破坏引发炎症免疫反应，这对成功的伤口愈合至关重要。先天性淋巴样细胞（ILC）是最近鉴定的免疫细胞群体，其驻留在上皮屏障表面如皮肤、肺和肠，并且在暴露于过敏原、病原体或化学刺激物后促进促炎或上皮修复功能。然而，ILC在调节皮肤伤口愈合中的潜在作用仍不明确。在这里，我们证明，皮肤损伤促进IL-33依赖性组2 ILC（ILC 2）的反应，这种反应的废除损害再上皮化和有效的伤口闭合。此外，我们提供的证据表明，一个类似的ILC 2反应是在人体皮肤的急性伤口操作。总之，这些结果表明，IL-33-应答性ILC 2是皮肤上皮和免疫系统之间的重要联系，用于促进损伤后皮肤完整性的恢复。
Breaches in the skin barrier initiate an inflammatory immune response that is critical for successful wound healing. Innate lymphoid cells (ILCs) are a recently identified population of immune cells that reside at epithelial barrier surfaces such as the skin, lung and gut and promote pro-inflammatory or epithelial repair functions following exposure to allergens, pathogens or chemical irritants. However, the potential role of ILCs in regulating cutaneous wound healing remains undefined. Here, we demonstrate that cutaneous injury promotes an IL-33-dependent group 2 ILC (ILC2) response and that abrogation of this response impairs re-epithelialization and efficient wound closure. Additionally, we provide evidence suggesting that an analogous ILC2 response is operational in acute wounds of human skin. Together, these results indicate that IL-33-responsive ILC2s are an important link between the cutaneous epithelium and the immune system, acting to promote the restoration of skin integrity following injury.