Immunodeficient mice have elevated numbers of NK cells in non-lymphoid tissues
Immunodeficient mice have elevated numbers of NK cells in non-lymphoid tissues
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DOI：
10.1016/j.yexcr.2006.08.019
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发表时间：
2006-11-15
影响因子：
3.7
通讯作者：
Sentman, Charles L.
中科院分区：
文献类型：
--
作者：
Grundy, Martin A.;Sentman, Charles L.
自然杀伤细胞（NK）是先天免疫应答的重要组成部分。它们有能力识别和杀死多种类型的肿瘤细胞，并促进对细胞内病原体的免疫。在这项研究中，我们使用一种新的原位分析方法分析了野生型和免疫缺陷小鼠体内NK细胞的原位定位。我们在B6和B6的组织中发现了NK细胞。Rag（-/-）小鼠和免疫缺陷小鼠的肺和肝脏中NK细胞百分比和NK细胞总数增加。这种增加不是由于NK细胞活化的增加。本研究描述了一种在复杂组织环境中识别NK细胞的方法，非淋巴组织中NK细胞的增加可能解释了在t细胞缺陷小鼠中观察到的NK细胞活性增加的大部分原因。(c) 2006爱思唯尔公司版权所有。
Natural killer (NK) cells are an important part of the innate immune response. They have the ability to recognize and kill many types of tumor cells and promote immunity against intracellular pathogens. In this study, we analyzed the in situ localization of NK cells within wildtype and immunodeficient mice using a novel in situ analysis method. we have identified NK cells in tissues of B6 and B6.Rag(-/-) mice and demonstrated an increase in the percentage of NK cells and the total number of NK cells in the lung and liver of immunodeficient mice. This increase was not due to an increase in NK cell activation. This study describes a means to identify NK cells within complex tissue environments, and the increase in NK cells in non-lymphoid tissues may explain much of the increased NK cell activity observed in T-cell-deficient mice. (c) 2006 Elsevier Inc. All rights reserved.