Surface characterization and blood compatibility of poly(ethylene terephthalate) modified by plasma surface grafting
Surface characterization and blood compatibility of poly(ethylene terephthalate) modified by plasma surface grafting
复制标题
DOI：
10.1016/j.surfcoat.2004.08.161
复制
发表时间：
2005-06
影响因子：
5.4
通讯作者：
Jin Wang;C. Pan;N. Huang;H. Sun;P. Yang;Y. Leng;J. Chen;G. Wan;P. Chu
中科院分区：
文献类型：
--
作者：
Jin Wang;C. Pan;N. Huang;H. Sun;P. Yang;Y. Leng;J. Chen;G. Wan;P. Chu
采用氩等离子体放电对人工心脏瓣膜缝合环用聚对苯二甲酸乙二酯（PET）进行表面处理，并接枝不同分子量的水溶性聚合物聚乙二醇（PEG）。通过接触角测量、X射线光电子能谱（XPS）和衰减全反射傅里叶变换红外光谱（ATR-FTIR）对等离子体处理和接枝膜的表面性质进行了测定。水的接触角从83.5°减小到38.7°，界面能从30.7 mN/m减小到6.3 mN/m。氧碳比从0.15增加到0.25。结果表明，PEG链已成功地接枝到PET膜表面。研究了表面改性PET与血液组分之间的相互作用，以评价样品的血液相容性。PET-PEG的活化部分凝血活酶时间（APTT）明显长于未处理的PET。扫描电子显微镜（SEM）和光学显微镜表明，粘附，聚集和形态改变的血小板显着减少PEG链接枝到PET膜。体外血液相容性试验表明，PEG接枝PET的血液相容性与PEG的分子量有关。当PEG的接枝分子量为6000时，其血液相容性最好。血液相容性的改善可以通过低界面自由能、PEG链的空间位阻效应和维持正常构象来解释。
Poly(ethlene terephthalate) (PET) used in artificial heart valve sewing rings were treated by argon plasma discharge and grafted by different molecular water-soluble polymer—polyethylene glycols (PEG). The surface properties of the plasma treated and grafted films were determined by contact angle measurement, X-ray photoelectron spectroscopy (XPS), and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR). The contact angle of water decreased from 83.5° to 38.7° and the interfacial energy diminished from 30.7 to 6.3 mN/m. The ratio of oxygen to carbon increased from 0.15 to 0.25. All the results revealed that PEG chains were successfully grafted onto the surface of the PET films. The interaction between the surface-modified PETs and blood components was investigated to evaluate the blood compatibility of the samples. Activated partial thromboplastin time (APTT) of the PET-PEG was significantly longer than that of the untreated PET. Scanning electron microscopy (SEM) and optical microscopy indicated that adhered, aggregated and morphologically changed platelets were significantly reduced by grafting PEG chains onto the PET films. The in vitro blood compatibility tests suggested that the blood compatibility of PET grafted with PEG was related to the molecular weight of PEG. The best blood compatibility was achieved when the grafted molecular weight of PEG was 6000. The hemocompatibility improvement can be explained by the low interfacial free energy, sterically hindered effects of PEG chains, and maintaining of the normal conformation.