ADAM12-S stimulates bone growth in transgenic mice by modulating chondrocyte proliferation and maturation
ADAM12-S stimulates bone growth in transgenic mice by modulating chondrocyte proliferation and maturation
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DOI：
10.1359/jbmr.060502
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发表时间：
2006-08-01
影响因子：
6.2
通讯作者：
Wewer, Ulla M.
中科院分区：
文献类型：
--
作者：
Kveiborg, Marie;Albrechtsen, Reidar;Wewer, Ulla M.
ADAM 12-S转基因小鼠表现出骨长度的显著增加，如股骨、胫骨和椎骨。ADAM 12-S对纵向骨生长的影响涉及软骨细胞增殖和成熟的调节，可能是通过蛋白水解活性和生长板中细胞-细胞外基质相互作用的改变。
ADAM12-S transgenic mice exhibit a pronounced increase in the length of bones, such as femur, tibia, and vertebrae. The effect of ADAM12-S on longitudinal bone growth involves the modulation of chondrocyte proliferation and maturation, likely through proteolytic activities and altered cell-extracellular matrix interactions in the growth plate.