Alpha synuclein is present in Lewy bodies in sporadic Parkinson's disease
Alpha synuclein is present in Lewy bodies in sporadic Parkinson's disease
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DOI：
10.1038/sj.mp.4000446
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发表时间：
1998-11-01
影响因子：
11
通讯作者：
Polymeropoulos, MH
中科院分区：
文献类型：
--
作者：
Mezey, E;Dehejia, AM;Polymeropoulos, MH
最近在一些家族性帕金森病（FPD）病例中发现了人类α突触核蛋白基因的错义突变。我们已经开发了一种抗体，该抗体识别人α突触核蛋白的C-末端12个氨基酸，并且已经证明α突触核蛋白是在帕金森病（PD）患者的退化神经元内发现的路易体的丰富组分。α突触核蛋白在散发性PD患者的路易体中的存在表明α突触核蛋白在PD的发病机制中起核心作用。
A missense mutation in the human alpha synuclein gene was recently identified in some cases of familial Parkinson's disease (FPD). We have developed an antibody that recognizes the C-terminal 12 amino acids of the human alpha synuclein protein and have demonstrated that alpha synuclein is an abundant component of the Lewy bodies found within the degenerating neurons of patients with Parkinson's disease (PD). The presence of alpha synuclein in Lewy bodies of sporadic PD patients suggests a central role for alpha synuclein in the pathogenesis of PD.