Integration of an Aerosol-Assisted Deposition Technique for the Deposition of Functional Biomaterials Applied to the Fabrication of Miniaturised Ion Sensors.
Integration of an Aerosol-Assisted Deposition Technique for the Deposition of Functional Biomaterials Applied to the Fabrication of Miniaturised Ion Sensors.
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DOI：
10.3390/nano11040938
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发表时间：
2021-04-07
期刊：
影响因子：
--
通讯作者：
Choy KL
中科院分区：
文献类型：
--
作者：
Ruiz-Gonzalez A;Choy KL
离子选择性电极处于当今研究的前沿，应用于医疗保健、农业和水质分析等领域。尽管对这些基于聚氯乙烯（PVC）凝胶的离子传感器的小型化进行了多次尝试，但迄今为止还没有开发出厚度低于微米范围并且使用开路电位操作的离子感测装置。这项工作报告的原因，这种厚度限制在钾选择性传感器。通过基于气溶胶辅助化学气相沉积的方法制造高度均匀的离子感测膜，导致具有27 ± 11 nm粗糙度的光滑表面。这种均匀性允许在亚微米尺度上系统地研究传感膜的性能和离子扩散特性。低于能斯特响应的灵敏度被发现在低厚度。这种降低灵敏度的性质进行了研究，并测量了薄膜的表面和本体组成的差异。在15 µm处发现了最佳构型，对Na+具有良好的选择性（KK+，Na+ = −1.8），检测限在10−4 M范围内，响应时间低于40 s。通过沉积保护层提高了传感器的稳定性，这将离子传感器的寿命延长至5周，同时保持了能斯特灵敏度。
Ion-selective electrodes are at the forefront of research nowadays, with applications in healthcare, agriculture and water quality analysis among others. Despite multiple attempts of miniaturization of these polyvinyl chloride (PVC) gel-based ion sensors, no ion-sensing devices with a thickness below the micrometer range, and operating using open circuit potential, have been developed so far. This work reports the causes of this thickness limitation in potassium-selective sensors. Highly homogeneous ion-sensing films were fabricated by a method based on aerosol assisted chemical vapour deposition, leading to smooth surfaces with 27 ± 11 nm of roughness. Such homogeneity allowed the systematic study of the performance and ionic diffusion properties of the sensing films at sub-micrometer scales. Sensitivities below the Nernst response were found at low thicknesses. The nature of this reduction in sensitivity was studied, and a difference in the superficial and bulk compositions of the films was measured. An optimal configuration was found at 15 µm, with a good selectivity against Na+ (KK+, Na+ = −1.8) a limit of detection in the range of 10−4 M and esponse time below 40 s. The stability of sensors was improved by the deposition of protective layers, which expanded the lifespan of the ion sensors up to 5 weeks while preserving the Nernst sensitivity.
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影响因子：
6.2
作者：
Gemene, Kebede L.;Shvarev, Alexey;Bakker, Eric
通讯作者：
Bakker, Eric
影响因子：
3
作者：
Cassidy, J;Mullen, D;Cullen, P
通讯作者：
Cullen, P
影响因子：
8.4
作者：
Gonzalez-Bellavista, Anna;Macanas, Jorge;Fabregas, Esteve
通讯作者：
Fabregas, Esteve
影响因子：
6.1
作者：
ATTIYAT, AS;CHRISTIAN, GD;BARTSCH, RA
通讯作者：
BARTSCH, RA
影响因子：
7.4
作者：
Bakker, E
通讯作者：
Bakker, E