The sero-epidemiology of human papillomavirus among Caucasian transplant recipients in the UK.
The sero-epidemiology of human papillomavirus among Caucasian transplant recipients in the UK.
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DOI：
10.1186/1750-9378-4-13
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发表时间：
2009-09-14
影响因子：
3.7
通讯作者：
Harwood, Catherine
中科院分区：
文献类型：
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作者：
Casabonne, Delphine;Waterboer, Tim;Harwood, Catherine
背景：尽管对高危粘膜人乳头瘤病毒（HPV）的研究非常深入，但对皮肤HPV的流行病学知之甚少。作为来自伦敦和牛津的器官移植受者（OTR）中皮肤鳞状细胞癌和HPV研究的一部分，我们调查了34种HPV类型的血清阳性率和危险因素结果：总体而言，86%的参与者对至少一种HPV血清阳性：41%为粘膜α型，33%为皮肤α型，57%为α型，56%为β型，47%为γ型，45%为其他类型（nu，mu，HPV 101和103）。在这两个中心，最常见的类型是HPV 6（伦敦和牛津分别为33%和26%），（24%和18%），HPV 15（26%和29%），HPV 17（25%和21%），HPV38 HPV49（19%和21%）、HPV4（27%和23%）、HPV65（30%和25%）、HPV95（22%和20%）、HPV1（33%和24%）和HPV63（28%和17%）。伦敦和牛津两地8种HPV感染率差异有统计学意义（P < 0.05）。对一个属的多个类型血清反应阳性的个体更可能对另一个属的多个类型血清反应。正如预期的那样，针对粘膜alphaHPV类型的抗体在年轻患者和女性中更常见。日光浴床使用和日光浴与多重gammaHPV血清阳性相关（P趋势= 0.007），异常涂片的自身病史与多重betaHPV血清活性相关（P = 0.01）。皮肤类型和其他自我报告的暴露于紫外线辐射的标志物与任何HPV类型都不一致。没有其他区别的流行病学特征的移植受体抗体对单一或多种HPV typeweridentified.CONCLUSION：粘膜HPV类型的调查结果与以前的研究结果一致。我们观察到来自两个地理位置接近的中心的器官移植受者之间HPV血清阳性率的差异，但没有发现与器官移植受者皮肤HPV血清阳性相关的明确危险因素。这些发现对解释未来的血清流行病学研究有意义，这些研究涉及HPV和OTR人群皮肤SCC之间的关联。
BACKGROUND: Despite intensive study of high-risk mucosal human papillomaviruses (HPV), little is known of the epidemiology of cutaneous HPV. As part of a study of cutaneous squamous cell carcinoma and HPV among organ transplant recipients (OTR) from London and Oxford, we investigated the seroprevalence and risk factors for 34 HPV types (detected using Luminex technology) among 425 Caucasian OTR without skin cancer.RESULTS: Overall, 86% of participants were seropositive to at least one HPV: 41% to mucosal alpha types, 33% to cutaneous alpha types, 57% to alpha types, 56% to beta, 47% to gamma types and 45% to other types (nu, mu, HPV101 and 103). In both centres, the most common types were HPV6 (33% and 26% for London and Oxford respectively), HPV8 (24% and 18%), HPV15 (26% and 29%), HPV17 (25% and 21%), HPV38 (23% and 21%), HPV49 (19% and 21%), HPV4 (27% and 23%), HPV65 (30% and 25%), HPV95 (22% and 20%), HPV1 (33% and 24%) and HPV63 (28% and 17%). The seroprevalence of 8 HPV types differed significantly (P < 0.05) between London and Oxford. Those individuals seropositive to multiple types of one genus were more likely to be seroreactive to multiple types of another genus. As expected, antibodies against mucosal alphaHPV types were more frequent in younger patients and among women. Sunbed use and sunbathing was associated with seropositivity to multiple gammaHPV (P-trend = 0.007) and self-history of abnormal smear was related to seroactivity to multiple betaHPV (P = 0.01). Skin type and other self reported markers of exposure to ultraviolet radiation were not consistently associated with any HPV types. No other distinguishing epidemiological features of transplant recipients with antibodies against single or multiple HPV types were identified.CONCLUSION: Findings for mucosal HPV types were in line with results from previous studies. We observed differences in HPV seroprevalence between organ transplant recipients from two geographically close centres but no clear risk factor was found associated with cutaneous HPV seropositivity among organ transplant recipients. These findings have implications for interpretation of future seroepidemiology studies addressing the association between HPV and cutaneous SCC in OTR populations.