MUC1 mucin is a negative regulator of Toll-like receptor signaling
MUC1 mucin is a negative regulator of Toll-like receptor signaling
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DOI：
10.1165/rcmb.2007-0336rc
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发表时间：
2008-03-01
影响因子：
6.4
通讯作者：
Kim, K. Chul
中科院分区：
文献类型：
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作者：
Ueno, Keiko;Koga, Takeshi;Kim, K. Chul
MUC 1（MUC 1在人类和Muc 1在非人类物种）是一种跨膜粘蛋白样糖蛋白，在衬于各种粘膜表面的上皮细胞以及造血细胞中表达。最近，我们发现Muc 1（-/-）小鼠对铜绿假单胞菌或其鞭毛蛋白的炎症反应比野生型小鼠更强，我们对培养细胞的研究表明，MUC 1/Muc 1抑制Toll样受体（TLR）5信号通路，表明其抗炎作用。在这里，我们证明了其他TLR信号转导（TLR 2，3，4，7和9）也被MUC 1/Muc 1抑制。本研究结果提示MUC 1/Muc 1可能在各种病原菌和病毒引起的气道感染和炎症过程中发挥重要作用。
MUC1 (MUC1 in humans and Muc1 in nonhuman species) is a transmembrane mucin-like glycoprotein expressed in epithelial cells lining various mucosal surfaces as well as hematopoietic cells. Recently, we showed that Muc1(-/-) mice exhibited greater inflammatory responses to Pseudomonas aeruginosa or its flagellin compared with their wild-type littermates, and our studies with cultured cells revealed that MUC1/Muc1 suppressed the Toll-like receptor (TLR) 5 signaling pathway, suggesting its anti-inflammatory role. Here we demonstrate that other TLR signaling (TLR2, 3,4, 7, and 9) is also suppressed by MUC1/Muc1. The results from this study suggest that MUC1/Muc1 may play a crucial role during airway infection and inflammation by various pathogenic bacteria and viruses.