Oxygen consumption, glycolysis, and sodium reabsorption in the hypothyroid rat kidney.
Oxygen consumption, glycolysis, and sodium reabsorption in the hypothyroid rat kidney.
复制标题
甲状腺功能减退大鼠肾脏的耗氧量、糖酵解和钠重吸收。
DOI：
10.1152/ajplegacy.1971.221.3.839
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发表时间：
1971
影响因子：
--
通讯作者：
V. Discala
中科院分区：
文献类型：
--
作者：
E. Holmes;V. Discala
霍姆斯、爱德华·W.、JR-和文森特·A.迪斯卡拉。甲状腺功能减退大鼠肾脏的耗氧量、糖酵解和钠重吸收。是。 J.生理学。 221(3)：839-843。 1971.-在对照大鼠和甲状腺功能减退大鼠的肾组织切片中测定耗氧量（Qog）和无氧糖酵解（Qco~）的速率。甲状腺功能减退症内髓组织中的 Qcoz 比对照大鼠低 19 c/0 (I’ < 0.05)。甲状腺功能减退症大鼠的非利尿动物皮层切片的 Qoz 比对照大鼠低 24% (a < 0.001)。对照组和甲状腺功能减退动物每 100 g 体重输注 2,500 uEq 钠后，甲状腺功能减退大鼠的肾小管钠重吸收率降低 2770 (P < 0.01)，皮质切片 Qo2 降低 30% (P < 0.001)。目前证明甲减大鼠肾中钠重吸收率降低以及有氧代谢和糖酵解代谢率降低，这可能为先前在这些动物中记录的夸大的尿钠排泄提供解释。
HOLMES, EDWARD W., JR-, AND VINCENT A. DISCALA. Oxygen consumption, glycolysis, and sodium reabsorption in the hypothyroid rat kidney. Am. J. Physiol. 221(3) : 839-843. 1971.-Rates of oxygen consumption (Qog) and anaerobic glycolysis (Qco~) were determined in renal tissue slices from control and hypothyroid rats. Qcoz was 19 c/0 lower (I’ < 0.05) in tissue from the inner medulla of hypothyroid than control rats. Qoz of cortical slices prepared from nondiuretic animals was 24% lower (a < 0.001) in hypothyroid than control rats. After control and hypothyroid animals had each been infused with 2,500 ,uEq of sodium per 100 g body wt, tubular sodium reabsorption was 2770 lower (P < 0.01) and Qo2 of cortical slices was 30% lower (P < 0.001) in hypothyroid than control rats. The present demonstration of a reduced rate of sodium reabsorption and reduced rate of aerobic and glycolytic metabolism in the hypothroid rat kidney may provide an explanation for the exaggerated natriuresis previously documented in these animals.