ADAPTATION AND DYNAMICS OF CAT RETINAL GANGLION-CELLS
ADAPTATION AND DYNAMICS OF CAT RETINAL GANGLION-CELLS
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DOI：
10.1113/jphysiol.1973.sp010308
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发表时间：
1973-01-01
影响因子：
5.5
通讯作者：
SHAPLEY, RM
中科院分区：
文献类型：
--
作者：
ENROTHCU.C;SHAPLEY, RM
1.脉冲/量子（I/Q）比测量为猫视网膜神经节细胞的视杆支配的纯中心线性方波响应的背景照明的函数。I/Q比在低背景下（暗适应状态）是恒定的，在高背景下（光适应状态）与背景的0·9次方成反比。从暗适应状态到光适应状态有一个突然的转变.可以将特定背景下的适应水平定义为比率（该背景下的I/Q比率）/（暗适应I/Q比率）。方波反应的时间过程与适应水平相关。这种反应在暗适应状态下持续，在过渡水平下部分短暂，并且神经节细胞的脉冲/量子比越低，反应越短暂。这对于中心和非中心小区都是正确的。5.测量了不同适应水平下中枢反应机制的频率响应。它在暗适应状态下是一个低通特性，随着细胞变得更加适应光，它逐渐变得更具有带通特性。用随时间变化的适应光测量适应开始的速度。脉冲/量子比在调节光开始的100毫秒内重置，并且在调节光开启的整个时间内保持在新值。这些结果可以用非线性反馈模型来解释。在该模型中，它被假定为水平细胞电位的指数函数控制从杆到双极的传输。该模型具有从暗适应状态到光适应状态的突然转变，并且其响应动力学与适应水平相关。
1. The impulse/quantum (I/Q) ratio was measured as a function of background illumination for rod‐dominated, pure central, linear square‐wave responses of retinal ganglion cells in the cat.2. TheI/Qratio was constant at low backgrounds (dark adapted state) and inversely proportional to the 0·9 power of the background at high backgrounds (the light adapted state). There was an abrupt transition from the dark‐adapted state to the light‐adapted state.3. It was possible to define the adaptation level at a particular background as the ratio (I/Qratio at that background)/(dark adaptedI/Qratio).4. The time course of the square‐wave response was correlated with the adaptation level. The response was sustained in the dark‐adapted state, partially transient at the transition level, and progressively more transient the lower the impulse/quantum ratio of the ganglion cell became. This was true both for on‐centre and off‐centre cells.5. The frequency response of the central response mechanism at different adaptation levels was measured. It was a low‐pass characteristic in the dark‐adapted state and became progressively more of a bandpass characteristic as the cell became more light‐adapted.6. The rapidity of onset of adaptation was measured with a time‐varying adapting light. The impulse/quantum ratio is reset within 100 msec of the onset of the conditioning light, and is kept at the new value throughout the time the conditioning light is on.7. These results can be explained by a nonlinear feedback model. In the model, it is postulated that the exponential function of the horizontal cell potential controls transmission from rods to bipolars. This model has an abrupt transition from dark‐ to light‐adapted states, and its response dynamics are correlated with adaptation level.