INFUSION OF TUMOR NECROSIS FACTOR TNF CAUSES AN INCREASE IN CIRCULATING TNF-BINDING PROTEIN IN HUMANS
INFUSION OF TUMOR NECROSIS FACTOR TNF CAUSES AN INCREASE IN CIRCULATING TNF-BINDING PROTEIN IN HUMANS
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DOI：
10.1016/1043-4666(90)90048-x
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发表时间：
1990-01-01
期刊：
影响因子：
3.8
通讯作者：
OLSSON I
中科院分区：
文献类型：
--
作者：
LANTZ M;MALIK S;OLSSON I
来自接受重组肿瘤坏死因子（rTNF）和重组干扰素-γ静脉输注的癌症患者的血清样品。（rIFN-γ）分析TNF和TNF结合蛋白（TNF-BP）。TNF-BP是跨膜TNF受体的可溶性片段，对TNF具有拮抗作用，并通过受体的蛋白水解裂解释放。在rTNF的60分钟输注期间，在30至60分钟后观察到rTNF的峰值血清水平，并且在注射IFN-γ的30至120分钟之间观察到循环TNF-BP的瞬时增加，峰值水平。单独使用不影响TNF和TNF-BP的水平。因此，rTNF的施用导致TNF-BP释放到循环中，其可调节TNF的全身和局部作用并影响其治疗功效。
Serum samples from cancer patients receiving intravenous infusions of recombinant tumor necrosis factor (rTNF) and recombinant interferon-.gamma. (rIFN-.gamma.) were analyzed for TNF and the TNF-binding protein (TNF-BP). TNF-BP is a soluble fragment of the transmembrane TNF receptor with antagonistic effects to TNF and is released by proteolytic cleavage of the receptor. During a 60-min infusion of rTNF, peak serum levels of rTNF were observed after 30 to 60 min and a transient increase in circulating TNF-BP was observed with peak levels between 30 and 120 min. injection of IFN-.gamma. alone did not affect the levels of TNF and TNF-BP. Thus administation of rTNF leads to release into the circulation of TNF-BP, which may modulate both systemic and local effects of TNF and influence its therapeutic efficacy.