ALTERATIONS IN MOUSE AGGRESSIVE-BEHAVIOR AND BRAIN MONOAMINE DYNAMICS AS A FUNCTION OF AGE
ALTERATIONS IN MOUSE AGGRESSIVE-BEHAVIOR AND BRAIN MONOAMINE DYNAMICS AS A FUNCTION OF AGE
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DOI：
10.1016/0031-9384(75)90126-2
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发表时间：
1975-01-01
影响因子：
2.9
通讯作者：
EVERETT, GM
中科院分区：
文献类型：
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作者：
BERNARD, BK;FINKELSTEIN, ER;EVERETT, GM
BALB、ICR和C57B1/6J系雄性小鼠分别在6周龄和30周龄时进行同种攻击行为测试。只有BALB小鼠在6周龄时具有攻击性，而BALB和ICR小鼠在30周龄时均具有攻击性。C57B1/6J小鼠在两个时间间隔内均未表现出攻击行为。住房条件的改变改变了ICR小鼠的攻击行为程度，但对C57B1/6J小鼠没有影响。用荧光法测定小鼠全脑水平、去甲肾上腺素（NE）和多巴胺（DA）的速率常数(k)和利用率(k)。与其他菌株相比，C57B1/6J小鼠的NE水平显著升高，BALB小鼠的DA水平显著升高。C57B1/6J小鼠的NE速率常数和利用率在6周时低于BALB或ICR小鼠，在30周时高于ICR小鼠，6周时多巴胺速率常数也高于BALB或ICR小鼠。BALB小鼠有持续较高DA利用率的趋势。这些发现与情感障碍的儿茶酚胺假说有关。
Male mice of the BALB, ICR and C57B1/6J strains were tested for conspecific aggressive behavior at either 6 or 30 weeks of age. Only the BALB animals were aggressive at 6 weeks of age while both BALB and ICR mice fought at 30 weeks of age. C57B1/6J mice did not show aggressive behavior at either of the time intervals studied. Changes in housing conditions altered the degree of aggressive behavior of the ICR but not the C57B1/6J mice. Whole-brain levels, rate constants (k) and utilization rates (K) of norepinephrine (NE) and dopamine (DA) in these mice were fluorometrically determined. C57B1/6J mice had significantly higher NE levels while BALB mice had higher DA levels, compared to the other strains at both time periods. The NE rate constants and utilization rates for C57B1/6J mice were lower at 6 weeks and higher at 30 weeks than either BALB or ICR mice as was the dopamine rate constant at the 6 week period. There was a tendency for BALB mice to have consistently higher DA utilization rates. These findings are discussed in relation to the catecholamine hypothesis of affective disorders.