Dissociation of neural regions associated with anticipatory versus consummatory phases of incentive processing
Dissociation of neural regions associated with anticipatory versus consummatory phases of incentive processing
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DOI：
10.1111/j.1469-8986.2007.00594.x
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发表时间：
2008-01-01
期刊：
影响因子：
3.7
通讯作者：
Pizzagalli, Diego A.
中科院分区：
文献类型：
--
作者：
Dillon, Daniel G.;Holmes, Avram J.;Pizzagalli, Diego A.
奖励延迟任务涉及纹状体和内侧额叶皮层。然而，先前的研究给出了更多的奖励而不是惩罚，这可能会导致信噪比的不必要差异。此外，是否特定的大脑区域专门参与预期或消费尚不清楚。我们使用了一个具有平衡激励传递和分析策略的任务，旨在确定特定于预期或消费的活动。两个独立样本（n = 13和n = 8）的反应时间数据证实了动机性反应。功能性磁共振成像显示被预期（前扣带）和消耗（眶和内侧额叶皮质）激活的区域。腹侧纹状体在预期奖励时活跃，但并不比进食时活跃。虽然这项研究在方法上有一些改进，并有助于阐明激励处理的神经基础，但需要在更大的样本中进行重复。
Incentive delay tasks implicate the striatum and medial frontal cortex in reward processing. However, prior studies delivered more rewards than penalties, possibly leading to unwanted differences in signal-to-noise ratio. Also, whether particular brain regions are specifically involved in anticipation or consumption is unclear. We used a task featuring balanced incentive delivery and an analytic strategy designed to identify activity specific to anticipation or consumption. Reaction time data in two independent samples (n = 13 and n = 8) confirmed motivated responding. Functional magnetic resonance imaging revealed regions activated by anticipation (anterior cingulate) versus consumption (orbital and medial frontal cortex). Ventral striatum was active during reward anticipation but not significantly more so than during consumption. Although the study features several methodological improvements and helps clarify the neural basis of incentive processing, replications in larger samples are needed.