Limb swelling in a pediatric sickle cell patient after revaccination with pneumococcal vaccine
Limb swelling in a pediatric sickle cell patient after revaccination with pneumococcal vaccine
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DOI：
10.1007/s11096-013-9888-3
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发表时间：
2014-04-01
影响因子：
2.4
通讯作者：
Suda, Katie J.
中科院分区：
文献类型：
--
作者：
Daniels, Calvin C.;Shelton, Chasity M.;Suda, Katie J.
病例（描述） 本报告描述了一起再次接种 23 价肺炎球菌多糖疫苗（PPSV23）后出现肢体肿胀的事件。一名患有镰状细胞病的 5 岁女性，手臂严重肿胀、水肿，很难将衬衫套在手臂上。前一天，她在接种脑膜炎球菌疫苗的同时接种了 PPSV23。她在事件发生前 2.5 年接种了 PPSV23 疫苗。该患者接受了镇痛药、止吐药和抗生素预防治疗，24 小时后手臂肿胀消退。重新接种疫苗和同时接种脑膜炎球菌疫苗之间的时间间隔缩短可能是原因之一。结论 虽然罕见，但重新接种疫苗后的肢体肿胀可能是特殊高危人群的一个问题，因为需要重复接种疫苗来保护肺炎球菌。
Case (description) This report describes an incident of limb swelling after revaccination with the 23-valent pneumococcal polysaccharide vaccine (PPSV23). A 5-year old female with sickle cell disease experienced severe arm swelling with edema to the extent that it was difficult to put a shirt over the arm. The day prior, she received PPSV23 concomitantly with the meningococcal vaccine. She had received the PPSV23 vaccine 2.5 years prior to the event. The patient was managed with analgesics, antiemetics, and antibiotic prophylaxis and the arm swelling resolved 24 h later. A decreased length of time between revaccination and concurrent administration with the meningococcal vaccine could have contributed. Conclusion Although rare, limb swelling after revaccination could be a concern in special at-risk populations where repeated vaccination is necessary for pneumococcal protection.