Dynamic Contrast-Enhanced Magnetic Resonance Imaging of Abdominal Solid Organ and Major Vessel: Comparison of Enhancement Effect between Gd-EOB-DTPA and Gd-DTPA
Dynamic Contrast-Enhanced Magnetic Resonance Imaging of Abdominal Solid Organ and Major Vessel: Comparison of Enhancement Effect between Gd-EOB-DTPA and Gd-DTPA
复制标题
DOI：
10.1002/jmri.21689
复制
发表时间：
2009-03-01
影响因子：
4.4
通讯作者：
Yamashita, Takenori
中科院分区：
文献类型：
--
作者：
Tamada, Tsutomu;Ito, Katsuyoshi;Yamashita, Takenori
目的：目的：评价钆对比剂动态增强磁共振成像（DCE-MRI）对腹部实质器官和主要血管增强的差异（Gd-EOB-DTPA：EOB）和钆二乙三胺五乙酸（Gd-DTPA）。材料和方法：共有13名健康志愿者接受了腹部MR检查的重复评估，使用剂量为0.1 mmol/kg体重的Gd-DTPA或剂量为0.025 mmol/kg体重的EOB进行DCE-MRI。kg体重。在造影剂注射前和动脉期（AP：25秒）、门脉期（PP：70秒）和平衡期（EP：3分钟）获得DCE图像。使用感兴趣区测量定义AP、PP和EP时肝脏的信号强度（SI）; AP时脾脏、肾皮质、肾髓质、胰腺、肾上腺、主动脉的SI; PP时门静脉和下腔静脉（IVC）的SI，并用于计算信号强度比（SIR）。肝脏（0.195 ± 0.140）、脾脏（1.35 ± 0.353）、肾皮质（1.58 ± 0.517）的平均SIR。肾髓质（0.548 ± 0.259）。胰腺（0.540 +/- 0.183），肾上腺（1.04 +/- 0.405），和主动脉（2.44 +/- 0.648）以及门静脉的平均SIR（1.85 +/- 0.477）和IVC EOB图像中PP处的（1.16 +/- 0.187）显著低于那些（0.337 +/- 0.200，1.99 +/- 0.443，2.01 +/- 0.474，0.742 +/- 0.336，0.771 ± 0.227，1.26 ± 0.442，3.22 ± 1.20。2.73 Gd-DTPA图像的平均值分别为± 0.429和1.68 ± 0.366（P均< 0.05）。EOB（0.529 +/- 0.124）和Gd-DTPA（0.564 +/- 0.139）之间PP时肝脏的平均SIR无显著差异。相反，EP时肝脏的平均SIR，EOB组（0.576 ± 0.167）显著高于Gd-DTPA组（0.396 ± 0.093）（P < 0.001）。结论：尽管Gd-EOB的晚期静脉相肝实质增强高于Gd-DTPA，但其动脉血管和实质增强较低，可能需要重新评估其剂量。
Purpose: To evaluate the differences in enhancement of the abdominal solid organ and the major vessel on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) obtained with gadolinium ethoxybenzyldiethylenetriamine pentaacetic acid (Gd-EOB-DTPA: EOB) and gadolintum diethylenetriamine pentaacetic acid (Gd-DTPA) in the same patients.Materials and Methods: A total of 13 healthy volunteers underwent repeat assessments of abdominal MR examinations with DCE-MRI using either Gd-DTPA at a dose of 0.1 mmol/kg body weight or EOB at a dose of 0.025 mmol/kg body weight. DCE images were obtained at precontrast injection and in the arterial phase (AP: 25 seconds), portal phase (PP: 70 seconds), and equilibrium phase (EP: 3 minutes). The signal intensities (SIs) of liver at AP, PP, and EP; the SIs of spleen, renal cortex, renal medulla, pancreas, adrenal gland, aorta at AP; and the SIs of portal vein and inferior vena cava (IVC) at PP were defined using region-of-interest measurements, and were used for calculation of signal intensity ratio (SIR).Results: The mean SIRs of liver (0.195 +/- 0.140), spleen (1.35 +/- 0.353), renal cortex (1.58 +/- 0.517). renal medulla (0.548 +/- 0.259). pancreas (0.540 +/- 0.183), adrenal gland (1.04 +/- 0.405), and aorta (2.44 +/- 0.648) at AP as well as the mean SIRs of portal vein (1.85 +/- 0.477) and IVC (1.16 +/- 0.187) at PP in the EOB images were significantly lower than those (0.337 +/- 0.200, 1.99 +/- 0.443, 2.01 +/- 0.474, 0.742 +/- 0.336, 0.771 +/- 0.227, 1.26 +/- 0.442, 3.22 +/- 1.20. 2.73 +/- 0.429, and 1.68 +/- 0.366, respectively) in the Gd-DTPA images (P < 0.05 each). There was no significant difference in mean SIR of liver at PP between EOB (0.529 +/- 0.124) and Gd-DTPA (0.564 +/- 0.139). Conversely, the mean SIR of liver at EP was significantly higher with EOB (0.576 +/- 0.167) than with Gd-DTPA (0.396 +/- 0.093) (P < 0.001).Conclusion: Lower arterial vascular and parenchymal enhancement with Gd-EOB, as compared with Gd-DTPA, may require reassessment of its dose, despite the higher late venous phase liver parenchymal enhancement.