Attenuated brain response to auditory word stimulation with sevoflurane - A functional magnetic resonance imaging study in humans
Attenuated brain response to auditory word stimulation with sevoflurane - A functional magnetic resonance imaging study in humans
复制标题
DOI：
10.1097/00000542-200507000-00006
复制
发表时间：
2005-07-01
期刊：
影响因子：
8.8
通讯作者：
Sebel, PS
中科院分区：
文献类型：
--
作者：
Kerssens, C;Hamann, S;Sebel, PS
背景资料：功能磁共振成像提供了一个令人信服的，改变大脑功能的新视角，但很少用于麻醉效果的研究。为了研究对言语记忆编码的影响，作者成像人类大脑的听觉词刺激功能磁共振成像在不同浓度的代理商没有以前研究，并测试记忆recovery.Methods：6名男性志愿者进行了研究呼吸0.0，2.0，和1.0%的潮气末七氟烷（清醒，深，和轻的状态，分别）通过喉罩。在每种情况下，他们通过封闭的耳机听到15个双音节英语名词。每个单词重复15次（1/s），然后休息15秒。血氧水平依赖性脑激活的刺激块与休息期间进行了评估与3-T西门子三扫描仪和20体素的空间范围阈值。记忆测试约1.5小时后恢复与听觉识别任务结果：扫描显示广泛的激活（P < 0.005，未校正）在清醒状态下，包括双侧上级颞叶、额叶和顶叶皮质，右侧枕叶皮质，双侧丘脑、纹状体、海马和小脑;在亮状态下激活更有限（双侧上级颞回、右侧丘脑、双侧顶叶皮层、左侧额叶皮层和右侧枕叶皮层）;在深状态下没有显著的与大脑皮层相关的激活。在识别测试中，受试者正确选择了77 +/- 12%的单词，而他们清醒时的“旧”，32 +/- 15和42 +/- 8%。（P < 0.01）分别校正了轻度和深度阶段。七氟烷诱导听觉血氧水平依赖性信号的剂量依赖性抑制，这可能会限制麻醉期间处理单词的能力并损害记忆。
Background: Functional magnetic resonance imaging offers a compelling, new perspective on altered brain function but is sparsely used in studies of anesthetic effect. To examine effects on verbal memory encoding, the authors imaged human brain response to auditory word stimulation using functional magnetic resonance imaging at different concentrations of an agent not previously studied, and tested memory after recovery.Methods: Six male volunteers were studied breathing 0.0, 2.0, and 1.0% end-tidal sevoflurane (awake, deep, and light states, respectively) via laryngeal mask. in each condition, they heard 15 two-syllable English nouns via closed headphones. Each word was repeated 15 times (1/s), followed by 15 s of rest. Blood oxygenation level dependent brain activations during blocks of stimulation versus rest were assessed with a 3-T Siemens Trio scanner and a 20-voxel spatial extent threshold. Memory was tested approximately 1.5 h after recovery with an auditory recognition task (chance performance = 33% correct).Results: Scans showed widespread activations (P < 0.005, uncorrected) in the awake state, including bilateral superior temporal, frontal, and parietal cortex, right occipital cortex, bilateral thalamus, striatum, hippocampus, and cerebellum; more limited activations in the light state (bilateral superior temporal gyrus, right thalamus, bilateral parietal cortex, left frontal cortex, and right occipital cortex); and no significant auditory-related activation in the deep state. During recognition testing, subjects correctly selected 77 +/- 12% of words presented while they were awake as "old," versus 32 +/- 15 and 42 +/- 8% (P < 0.01) correct for the light and deep stages, respectively.Conclusions: Sevoflurane induces dose-dependent suppression of auditory blood oxygenation level dependent signals, which likely limits the ability of words to be processed during anesthesia and compromises memory.