Sex-dependent effects of paternal deprivation and chronic variable stress on novel object recognition in adult California mice (Peromyscus californicus)
Sex-dependent effects of paternal deprivation and chronic variable stress on novel object recognition in adult California mice (Peromyscus californicus)
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DOI：
10.1016/j.yhbeh.2019.104610
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发表时间：
2020-01-01
影响因子：
3.5
通讯作者：
Glasper, E. R.
中科院分区：
文献类型：
--
作者：
Agarwal, P.;Palin, N.;Glasper, E. R.
早期生活压力暴露可能使成年后易患精神疾病和认知障碍。众所周知，早期应激可以性别依赖的方式失调下丘脑-垂体-肾上腺(HPA)轴。具体地说，长期中断母子关系(例如母体分离)的单亲啮齿动物模型显示，与雌性相比，成年雄性在应激反应方面发生了更大的变化。此外，慢性早期生活压力(例如，有限的卧铺模式)对男性认知功能的损害比女性更大。然而，早期生活应激和晚年慢性HPA轴激活对认知的性别依赖性影响还没有得到很好的表征。在这里，我们利用双亲加州小鼠(Permyscus CalforNicus)来模拟父亲剥夺(PD)的早期生活逆境。父亲要么留在巢中(双亲照料)，要么在出生后一天永久离开(PND)1。成年后代暴露于日常操作(对照组)或慢性可变压力(CVS；三种应激源，持续七天)。在最终应激源24小时后，新的物体识别(NOR)任务开始，随后收集血清进行皮质酮(CORT)分析。与性别或养育方式无关，CVS增加了皮质醇。由于CVS和PD，NOR任务的获取期间的探索增加了。在NOR测试中，没有压力的女性表现出比没有压力的男性更大的差异分数(即，增强的识别记忆)。然而，CVS的加入减少了女性的差异得分--这一影响在接触CVS的男性中没有观察到。总体而言，这些数据表明，新生儿的父亲经历、性别和慢性压力有助于双亲物种的探索性行为、认知和应激激素浓度。
Early-life stress exposure can confer vulnerability for development of psychiatric illnesses and impaired cognition in adulthood. It is well-known that early-life stress can dysregulate the hypothalamic-pituitary-adrenal (HPA) axis in a sex-dependent manner. Specifically, uniparental rodent models of prolonged disrupted mother-offspring relationships (e.g., maternal separation) have demonstrated greater alterations in stress responsivity in adult males, compared to females. Also, chronic early-life stressors (e.g., limited bedding model) impair cognitive function in males more than females. However, the sex-dependent effects of early-life stress and later-life chronic HPA axis activation on cognition have not been well-characterized. Here, we utilized the biparental California mouse (Peromyscus californicus) to model the early-life adversity of paternal deprivation (PD). Fathers either remained in the nest (biparental care) or were permanently removed (PD) on postnatal day (PND) 1. Adult offspring were exposed to daily handling (control) or chronic variable stress (CVS; three stressors for seven days). Twenty-four hours after the final stressor, the novel object recognition (NOR) task commenced, followed by serum collection for corticosterone (CORT) analysis. Independent of sex or rearing, CVS increased CORT. Exploration during acquisition for the NOR task was increased as a result of CVS and PD. During NOR testing, non-stressed females exhibited greater difference scores (i.e., increased recognition memory), compared to non-stressed males. However, the addition of CVS diminished difference scores in females - an effect not observed in CVS-exposed males. Overall, these data suggest that neonatal paternal experience, sex, and chronic stress contribute to exploratory behavior, cognition, and stress hormone concentrations in a biparental species.