ALPHA-FOLD PLUS BETA-FOLD REVISITED - SOME FAVORED MOTIFS
ALPHA-FOLD PLUS BETA-FOLD REVISITED - SOME FAVORED MOTIFS
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DOI：
10.1016/0969-2126(93)90026-d
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发表时间：
1993-10-15
期刊：
影响因子：
5.7
通讯作者：
THORNTON, JM
中科院分区：
文献类型：
--
作者：
ORENGO, CA;THORNTON, JM
背景资料：通过进行广泛的成对结构比较，我们最近从Brookhaven蛋白质结构数据库中确定了一组独特的折叠。这种分析揭示了相当大的子群的α + β倍，这使我们重新审视的类型的折叠发生在这一类和它们之间的关系的性质之间的相似性。结果：两个主要的α + β倍组可以区分。在第一种中，由于α-螺旋和β-链占据单独且不同的层，被描述为α-β三明治，分裂的β-α-β基序经常出现。另一组，α-β卷，包含较少的螺旋和更多样化。在这些细胞中，β-折叠折叠或翻转，为α-螺旋提供了一个摇篮。一个β α-曲流模被发现在整个α + β Class.Conclusion：虽然许多α-β三明治有非常相似的折叠，很少有共同的功能和活性位点分布在整个表面的折叠。α-β夹心结构容纳一系列功能的能力表明它是一种稳定的折叠，并且能够适应许多位点以满足不同的功能要求。相比之下，在α-β辊中，具有相同辊类型的折叠部通常具有共同的功能。
Background: By performing extensive pairwise structural comparisons, we recently identified a set of unique folds from the Brookhaven protein structure data bank. This analysis revealed considerable similarities between a large subgroup of the alpha+beta folds, which led us to re-examine the types of folds occurring in this class and the nature of the relationships between them.Results: Two major alpha+beta fold groups can be distinguished. In the first, described as alpha-beta sandwiches because alpha-helices and beta-strands occupy separate and distinct layers, a split beta alpha beta motif recurs frequently. The other group, alpha-beta rolls, contains fewer helices and is more diverse. In these, the beta-sheet has folded or rolled over, providing a cradle for the alpha-helix. A beta beta beta alpha-meander motif is found throughout the alpha+beta class.Conclusion: Although many alpha-beta sandwiches have very similar folds, few share common functions and the active sites are distributed over the whole surface of the fold. The ability of the alpha-beta sandwich to accommodate a range of functions suggests that it is a stable fold and one that is able to adapt a number of sites to satisfy different functional requirements. In contrast, amongst the alpha-beta rolls, folds having the same roll type often have common functions.