MIF gene rs755622 polymorphism positively associated with acute coronary syndrome in Chinese Han population: case-control study
MIF gene rs755622 polymorphism positively associated with acute coronary syndrome in Chinese Han population: case-control study
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MIF基因rs755622多态性与中国汉族人群急性冠状动脉综合征呈正相关：病例对照研究
DOI：
10.1038/s41598-019-56949-z
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发表时间：
2020-01-10
影响因子：
4.6
通讯作者：
Yang, Yi-Ning
中科院分区：
文献类型：
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作者：
Du, Guo-Li;Luo, Jun-Yi;Yang, Yi-Ning
巨噬细胞迁移抑制因子（MIF）已被认为是动脉粥样硬化发病机制中的主要参与者。本研究确定了MIF基因多态性与急性冠状动脉综合征（ACS）之间的关联。对中国汉族人群中1153名健康对照者和699名ACS病例进行MIF基因多态性分析（rs755622、rs1007888和rs2096525）。还随机测量了部分 ACS 患者 (139/19.9%) 和健康对照 (129/11.2%) 的血浆 MIF 水平。大多数参与者，包括健康对照和 ACS 患者，携带 rs755622 GG（63.1% vs. 56.7%）和 CG 基因型（33.1% vs. 38.9%）以及 rs755622 的 G 等位基因（分别为 79.6% vs. 76.1%），而 CC 基因型（3.8% vs. 4.4%）和 C 等位基因（20.4%） vs. 23.9%）运营商最低。多变量logistic回归分析显示，与其他基因型相比，rs755622 C等位基因携带者患ACS的风险较高（AOR = 1.278，95% CI：1.042-1.567）。此外，CC基因型携带者的血浆MIF水平高于其他基因型携带者。 CC基因型的ACS患者的MIF水平显着高于携带GG基因型的ACS患者和携带3种不同MIF基因rs755622基因型的健康对照。我们的研究结果表明，MIF 基因 rs755622 变异 C 等位基因与 ACS 风险增加相关。 MIF基因多态性的鉴定可能有助于预测ACS的风险。
Macrophage migration inhibitory factor (MIF) has been recognized as a major player in the pathogenesis of atherosclerosis. This study determined the association between polymorphisms of MIF gene and acute coronary syndrome (ACS). The polymorphism of MIF gene (rs755622, rs1007888 and rs2096525) was analyzed in 1153 healthy controls and 699 ACS cases in Chinese Han population. Plasma MIF level was also measured in part of ACS patients (139/19.9%) and healthy controls (129/11.2%) randomly. Most participants including healthy controls and ACS patients carried rs755622 GG (63.1% vs. 56.7%) and CG genotypes (33.1% vs. 38.9%) and G allele of rs755622 (79.6% vs. 76.1%, respectively), while CC genotype (3.8% vs. 4.4%) and C allele (20.4% vs. 23.9%) carriers were the lowest. Multivariate logistic regression analysis showed that carriers with rs755622 C allele had a higher risk of ACS compared to other genotypes (AOR = 1.278, 95% CI: 1.042-1.567). In addition, CC genotype carriers had the highest plasma levels of MIF than other genotype carriers. The MIF level in ACS patients with CC genotype was significantly higher than ACS patients carrying GG genotype and healthy controls carrying 3 different genotypes of MIF gene rs755622. Our findings indicate that MIF gene rs755622 variant C allele is associated with increased risk of ACS. Identification of this MIF gene polymorphism may help for predicting the risk of ACS.