High-resolution morphological and biochemical imaging of articular cartilage of the ankle joint at 3.0 T using a new dedicated phased array coil: in vivo reproducibility study
High-resolution morphological and biochemical imaging of articular cartilage of the ankle joint at 3.0 T using a new dedicated phased array coil: in vivo reproducibility study
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DOI：
10.1007/s00256-008-0474-z
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发表时间：
2008-06-01
影响因子：
2.1
通讯作者：
Trattnig, Siegfried
中科院分区：
文献类型：
--
作者：
Welsch, Goetz H.;Mamisch, Tallal C.;Trattnig, Siegfried
目的本研究的目的是评估的可行性和重复性的高分辨率磁共振成像（MRI）和定量T2映射的距小腿软骨在临床适用的扫描时间内使用一种新的专用踝关节线圈和高场MRI.Materials和方法10名健康志愿者（平均年龄32.4岁）进行了MRI的踝关节。作为形态学序列，将质子密度脂肪抑制快速自旋回波（PD-FS-TSE）作为参考，与稳态进动三维真快速成像（TrueFISP）进行比较。此外，使用多回波自旋回波T2方法制备生化定量T2成像。由三名不同的观察员对矢状切片进行三次数据分析，计划在各向同性3D-TrueFISP上进行;作为形态学参数，评估软骨厚度，并对T2弛豫时间进行感兴趣区域（ROI）评价。生殖率被确定为每个志愿者的变异系数（CV）;平均值为均方根（RMSA），以百分比表示;结果3D-TrueFISP测量的距小腿关节软骨厚度值明显高于常规测量值与PD-FS-TSE（范围为0.74至0.99 mm）相比，两种形态学序列（范围为1.07至1.14 mm）均显示出相当好的结果，RMSA为7.1至8.5%。T2弛豫时间为54 ms，RMSA为3.2 ~ 4.7%。结论本研究可在临床可实现的扫描时间内对软骨厚度和T2弛豫时间进行高重复性评估，为进一步研究患者群体提供了新的可能性。
Objective The objective of this study was to evaluate the feasibility and reproducibility of high-resolution magnetic resonance imaging (MRI) and quantitative T2 mapping of the talocrural cartilage within a clinically applicable scan time using a new dedicated ankle coil and high-field MRI.Materials and methods Ten healthy volunteers (mean age 32.4 years) underwent MRI of the ankle. As morphological sequences, proton density fat-suppressed turbo spin echo (PD-FS-TSE), as a reference, was compared with 3D true fast imaging with steady-state precession (TrueFISP). Furthermore, biochemical quantitative T2 imaging was prepared using a multi-echo spin-echo T2 approach. Data analysis was performed three times each by three different observers on sagittal slices, planned on the isotropic 3D-TrueFISP; as a morphological parameter, cartilage thickness was assessed and for T2 relaxation times, region-of-interest (ROI) evaluation was done. Reproducibility was determined as a coefficient of variation (CV) for each volunteer; averaged as root mean square (RMSA) given as a percentage; statistical evaluation was done using analysis of variance.Results Cartilage thickness of the talocrural joint showed significantly higher values for the 3D-TrueFISP (ranging from 1.07 to 1.14 mm) compared with the PD-FS-TSE (ranging from 0.74 to 0.99 mm); however, both morphological sequences showed comparable good results with RMSA of 7.1 to 8.5%. Regarding quantitative T2 mapping, measurements showed T2 relaxation times of about 54 ms with an excellent reproducibility (RMSA) ranging from 3.2 to 4.7%.Conclusion In our study the assessment of cartilage thickness and T2 relaxation times could be performed with high reproducibility in a clinically realizable scan time, demonstrating new possibilities for further investigations into patient groups.