Different prognostic value of white blood cell subtypes in patients with acute cerebral infarction
Different prognostic value of white blood cell subtypes in patients with acute cerebral infarction
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DOI：
10.1016/j.atherosclerosis.2012.02.042
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发表时间：
2012-06-01
期刊：
影响因子：
5.3
通讯作者：
Heo, Ji Hoe
中科院分区：
文献类型：
--
作者：
Kim, Jinkwon;Song, Tae-Jin;Heo, Ji Hoe
目的：我们的目的是调查的关系，每个白色血细胞（WBC）亚型与神经系统的严重程度和结果在急性strok.Methods：我们包括779例首次急性脑梗死72小时内症状发作。我们研究了入院时外周血WBC亚型计数与（1）初始卒中严重程度;（2）1周内卒中严重程度的早期变化;（3）3个月时的功能结局之间的关系。结果：较高的总WBC和中性粒细胞计数与入院时更严重的卒中相关（p < 0.001）。相比之下，较低的淋巴细胞计数与入院后第一周内较小的改善相关（p < 0.05），3个月时功能结局较差（OR = 0.706/1000淋巴细胞计数/mm（3），p = 0.020）。我们的研究值得进一步研究每种WBC亚型在缺血性损伤中的作用以及急性脑梗死患者入院时测量的WBC亚型的不同预后价值。中风(C)2012爱思唯尔爱尔兰有限公司保留所有权利。
Objective: We aimed to investigate the relationship of each white blood cells (WBC) subtype with neurologic severity and outcome in acute stroke.Methods: We included 779 patients with first-ever acute cerebral infarction within 72 h after symptom onset. We investigated the association between counts for WBC subtypes in peripheral blood at admission and (1) initial stroke severity; (2) early change in stroke severity within one week; and (3) functional outcome at three months.Results: Higher total WBC and neutrophil counts were associated with more severe stroke at admission (p < 0.001). In contrast, lower lymphocyte counts were associated with a lesser improvement during the first week after admission (p < 0.05) and with poor functional outcome at three months (OR = 0.706 per 1000 lymphocyte counts/mm(3), p = 0.020).Conclusions: Our study merits further investigation on the role of each WBC subtype in ischemic injury and different prognostic value of WBC subtypes measured at admission in acute stroke. (C) 2012 Elsevier Ireland Ltd. All rights reserved.