Brief Communication: In Vitro Activation of Armed Macrophages and the Therapeutic Application in Mice
Brief Communication: In Vitro Activation of Armed Macrophages and the Therapeutic Application in Mice
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简短交流：武装巨噬细胞的体外激活及其在小鼠中的治疗应用
DOI：
10.1093/jnci/52.6.1917
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发表时间：
1974
期刊：
影响因子：
--
通讯作者：
W. Otter
中科院分区：
文献类型：
--
作者：
H. Loveren;W. Otter
当免疫脾淋巴细胞与特异性靶细胞孵育时，会释放特异性巨噬细胞武装因子（SMAF）。与免疫脾细胞和特异性靶细胞孵育可增强武装巨噬细胞的细胞毒性。同种异体活化臂和同种异体免疫巨噬细胞之间的细胞毒性差异不显著。在体外武装和激活的同系巨噬细胞显着延长DBA/2小鼠注射同系SL 2淋巴瘤细胞的生存时间。
A specific macrophage arming factor (SMAF) was released when immune spleen lymphocytes were incubated with specific target cells. Cytotoxicity of armed macrophages was enhanced by incubation with immune spleen cells and the specific target cells. The difference in cytotoxicity between allogeneic activated-armed and allogeneic immune macrophages was not significant. In vitro armed and activated syngeneic macrophages significantly prolonged survival time in DBA/2 mice given injections of syngeneic SL2 lymphoma cells.