OCCUPATIONAL RISK-FACTORS FOR BLADDER-CANCER - RESULTS FROM A CASE-CONTROL STUDY IN MONTREAL, QUEBEC, CANADA
OCCUPATIONAL RISK-FACTORS FOR BLADDER-CANCER - RESULTS FROM A CASE-CONTROL STUDY IN MONTREAL, QUEBEC, CANADA
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DOI：
10.1093/oxfordjournals.aje.a117207
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发表时间：
1994-12-15
影响因子：
5
通讯作者：
GERIN, M
中科院分区：
文献类型：
--
作者：
SIEMIATYCKI, J;DEWAR, R;GERIN, M
在加拿大魁北克蒙特利尔进行了一项以人群为基础的病例对照研究，探讨各种癌症与职业暴露之间的关系。在1979年至1986年期间，对484名经病理证实的膀胱癌患者和1，879名在其他地点患癌症的对照者进行了访谈，并对533名人口对照者进行了一系列访谈。这些主题的工作历史进行了评估，由一个小组的化学家/药剂师的证据暴露于294工作场所的化学品，并获得相关的非职业混杂因素的信息。在初步分析和文献回顾的基础上，选择了19个职业、11个行业和23种物质进行深入的多变量分析。进行Logistic回归分析，以估计这些职业环境与膀胱癌之间的比值比。有微弱的证据表明，以下物质可能是膀胱癌的危险因素：天然气燃烧产物，芳香胺，镉化合物，摄影产品，丙烯酸纤维，聚乙烯，二氧化钛和氯。在评估的物质中，没有证据表明有关联的是苯并（a）芘，皮革粉尘和甲醛;几个职业和行业与膀胱癌有关，包括机动车驾驶员和纺织印染工。
A population-based case-control study of the associations between various cancers and occupational exposures was carried out in Montreal, Quebec, Canada. Between 1979 and 1986, 484 persons with pathologically confirmed cases of bladder cancer and 1,879 controls with cancers at other sites were interviewed, as was a series of 533 population controls. The job histories of these subjects were evaluated by a team of chemist/hygienists for evidence of exposure to a list of 294 workplace chemicals, and information on relevant non-occupational confounders was obtained. On the basis of results of preliminary analyses and literature review, 19 occupations, 11 industries, and 23 substances were selected for in-depth multivariate analysis. Logistic regression analyses were carried out to estimate the odds ratio between each of these occupational circumstances and bladder cancer. There was weak evidence that the following substances may be risk factors for bladder cancer: natural gas combustion products, aromatic amines, cadmium compounds, photographic products, acrylic fibers, polyethylene, titanium dioxide, and chlorine. Among the substances evaluated which showed no evidence of an association were benzo(a)pyrene, leather dust, and formaldehyde; Several occupations and industries were associated with bladder cancer, including motor vehicle drivers and textile dyers.