MRI Evidence of Neuropathic Changes in Former College Football Players
MRI Evidence of Neuropathic Changes in Former College Football Players
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DOI：
10.1097/jsm.0000000000000391
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发表时间：
2018-03-01
影响因子：
2.7
通讯作者：
Divine, Jon
中科院分区：
文献类型：
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作者：
Adler, Caleb M.;DelBello, Melissa P.;Divine, Jon
目的：探讨退役后参加大学生足球运动对神经健康的影响。我们假设，相对皮质变薄和损失的白色物质的完整性将被观察到前球员。设计图：前NCAA一级足球运动员与人口统计学上相似的田径运动员在皮质厚度和白色物质完整性方面进行了比较。设置：参与者在辛辛那提大学成像研究中心参加MRI扫描。参会人员：11名前足球运动员和10名人口统计学上相似的田径运动员，主要结果测量：使用双尾Student t检验比较组间的标准化皮质厚度。作为二次分析，计算皮质厚度与脑震荡次数之间的斯皮尔曼相关系数。使用双尾Student t检验比较了两组之间额叶白色束和内囊中感兴趣区域的各向异性分数。结果：足球运动员表现出显着较低的皮质厚度内的部分额叶和颞叶皮层。受累额区包括左额极和右额上级回。受影响的颞区包括部分上级颞回，左颞下回，右中和上级颞回。皮质厚度与大多数这些区域报告的脑震荡数量呈负相关。此外，相对于对照组，较驯服的足球运动员的右侧内囊的各向异性分数较低。结论：这些发现表明，即使在停止了经常性的头部打击之后，高水平的大学橄榄球比赛的至少一些后果仍然存在。长期的研究是必要的，以检查潜在的认知和功能的影响，持续的皮质萎缩。
Objective: To examine effects of participating in collegiate football on neural health several years after retirement. We hypothesized that relative cortical thinning and loss of white matter integrity would be observed in former players. Design: Former NCAA Division I football players were compared with demographically similar track-and-field athletes with regard to cortical thickness and white matter integrity. Setting: Participants participated in MRI scans at the Center for Imaging Research at the University of Cincinnati. Participants: Eleven former football players and 10 demographically similar track-and-field athletes, Main Outcome Measures: Normalized cortical thickness was compared between groups using 2-tailed Student t test. As a secondary analysis, Spearman correlation coefficient was calculated between cortical thickness and number of concussions. Fractional anisotropy for regions-of-interest placed in frontal white matter tracts and internal capsule were compared between groups using 2-tailed Student t test. Results: Football players showed significantly lower cortical thickness within portions of both the frontal and temporal cortex. Affected frontal regions included left frontal pole and right superior frontal gyrus. Affected temporal regions included portions of the superior temporal gyrus, left inferior temporal gyrus, and right middle and superior temporal gyri. Cortical thickness inversely correlated with number of reported concussions over most of these regions. In addition, fractional anisotropy was lower in the right internal capsule of tamer football players, relative to controls. Conclusions: These findings suggest that at least some consequences of high-level collegiate football play persist even after the cessation of regular head blows. Longer-term studies are warranted to examine potential cognitive and functional implications of sustained cortical atrophy.