Dynamical systems approach to endothelial heterogeneity.
Dynamical systems approach to endothelial heterogeneity.
复制标题
内皮异质性的动力系统方法。
DOI：
10.1161/circresaha.111.261701
复制
发表时间：
2012-06-22
影响因子：
20.1
通讯作者：
Aird WC
中科院分区：
文献类型：
--
作者：
Regan ER;Aird WC
在这里，我们重新审视我们目前对内皮异质性分子基础的理解。我们引入多稳定性作为血管生物学的新解释框架。我们利用非线性动力学领域提出了一个动力学系统框架，用于建模多稳定性及其衍生属性，包括鲁棒性、记忆性和可塑性。我们的观点允许对内皮调节的系统级特征进行概念和定量描述。
Here we reexamine our current understanding of the molecular basis of endothelial heterogeneity. We introduce multistability as a new explanatory framework in vascular biology. We draw on the field of non-linear dynamics to propose a dynamical systems framework for modeling multistability and its derivative properties, including robustness, memory, and plasticity. Our perspective allows for both a conceptual and quantitative description of system-level features of endothelial regulation.